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Gene Review:

Gfra3 - glial cell line derived neurotrophic...

Mus musculus

Synonyms: GDNF family receptor alpha-3, GDNF receptor alpha-3, GDNFR-alpha-3, GFR alpha-3, GFR-alpha-3, ...

Widenfalk, J. et al., Nomoto, S. et al., Bolon, B. et al., Trupp, M. et al.

Widenfalk, Tomac, Lindqvist, Hoffer, Olson,

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High impact information on Gfra3

Developmentally regulated expression of GFR alpha-3 was, however, detected in several peripheral organs and ganglia [1].
GFR alpha-2, but not GFR alpha-3 mRNA expression was highly induced in several nuclei after stimulation with kainic acid [1].
We report here the identification of a gene, termed GFRalpha-3 (glial cell line-derived neurotrophic factor family receptor alpha-3), related to GFRalpha-1 and GFRalpha-2 (also known as GDNFR-alpha and GDNFR-beta), and describe distribution of GDNFalpha-3 in the nervous system and other parts of the mouse body during development and in the adult [2].
At the protein level, mouse GFR alpha-3 is 35% identical to mouse GDNFR alpha and 36% identical to mouse NTNR alpha [3].
Expression data revealed that Gfr alpha-3 is expressed during development in the adrenal medulla, sensory and autonomic ganglia and their projections, while Art is found in contiguous mesenchymal domains (especially skeleton) and in certain nerves [4].

Other interactions of Gfra3

Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha [3].

Analytical, diagnostic and therapeutic context of Gfra3

Northern blot analysis showed that GFR alpha-3 is expressed in fetal mouse heart, brain, lung, and kidney and adult heart [3].

References

Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Trupp, M., Raynoschek, C., Belluardo, N., Ibáñez, C.F. Mol. Cell. Neurosci. (1998) [Pubmed]
GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells. Widenfalk, J., Tomac, A., Lindqvist, E., Hoffer, B., Olson, L. Eur. J. Neurosci. (1998) [Pubmed]
Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. Nomoto, S., Ito, S., Yang, L.X., Kiuchi, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Bolon, B., Jing, S., Asuncion, F., Scully, S., Pisegna, M., Van, G.Y., Hu, Z., Yu, Y.B., Min, H., Wild, K., Rosenfeld, R.D., Tarpley, J., Carnahan, J., Duryea, D., Hill, D., Kaufman, S., Yan, X.Q., Juan, T., Christensen, K., McCabe, J., Simonet, W.S. Toxicologic pathology. (2004) [Pubmed]

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