The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GFRA2  -  GDNF family receptor alpha 2

Homo sapiens

Synonyms: GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNF receptor beta, GDNFR-alpha-2, GDNFR-beta, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GFRA2


High impact information on GFRA2


Biological context of GFRA2

  • We identified six sequence variants of GFRA2, four of which did not affect the amino acid sequence of the GFRalpha-2 protein [1].
  • GFRA2 has nine coding exons that are similar in size and organization to those of other GFRA family genes [1].

Anatomical context of GFRA2


Analytical, diagnostic and therapeutic context of GFRA2

  • Using quantitative real-time PCR, we measured the expression of some miRNA precursors in human BE(2)-C cells that express GFRalpha2 but not GFRalpha1 [4].
  • Sequence analysis indicated that GDNFR-beta is also a GPI-linked protein, with 47% identity to GDNFR-alpha [6].


  1. Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Vanhorne, J.B., Gimm, O., Myers, S.M., Kaushik, A., von Deimling, A., Eng, C., Mulligan, L.M. Hum. Genet. (2001) [Pubmed]
  2. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L., Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R.B., Cate, R.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Trupp, M., Raynoschek, C., Belluardo, N., Ibáñez, C.F. Mol. Cell. Neurosci. (1998) [Pubmed]
  4. Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2. Yoong, L.F., Wan, G., Too, H.P. J. Neurochem. (2006) [Pubmed]
  5. GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. Josephson, A., Widenfalk, J., Trifunovski, A., Widmer, H.R., Olson, L., Spenger, C. J. Comp. Neurol. (2001) [Pubmed]
  6. Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: a novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factors. Wang, C.Y., Ni, J., Jiang, H., Hsu, T.A., Dugich-Djordjevic, M., Feng, L., Zhang, M., Mei, L., Gentz, R., Lu, B. Neuroscience (1998) [Pubmed]
WikiGenes - Universities