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Gene Review

Gfra2  -  glial cell line derived neurotrophic...

Mus musculus

Synonyms: GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNF receptor beta, GDNFR-alpha-2, GDNFR-beta, ...
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Disease relevance of Gfra2

  • In the Gfra2-/- mice, density of substance P-containing myenteric ganglion cells and nerve bundles in the myenteric ganglion cell layer was significantly reduced, and transit of test material through small intestine was 25% slower compared to wild-type mice [1].

High impact information on Gfra2


Biological context of Gfra2

  • In accordance with the phenotype of the mutant motoneurons observed in culture we found the loss of distinct groups of motoneurons, identified by several markers, in the Gfra1(-/-) spinal cords but no gross defects in the Gfra2(-/-) mutant [6].
  • Two candidate genes, GFR alpha 2 and GnRH, that were previously mapped to that region and the functions of which in spermatogenesis are well established were not altered in DMS [7].

Anatomical context of Gfra2


Other interactions of Gfra2


Analytical, diagnostic and therapeutic context of Gfra2


  1. Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor alpha2. Rossi, J., Herzig, K.H., Võikar, V., Hiltunen, P.H., Segerstråle, M., Airaksinen, M.S. J. Clin. Invest. (2003) [Pubmed]
  2. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Klein, R.D., Sherman, D., Ho, W.H., Stone, D., Bennett, G.L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J.A., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C.E., Takahashi, M., Rosenthal, A. Nature (1997) [Pubmed]
  3. Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. Nanobashvili, A., Airaksinen, M.S., Kokaia, M., Rossi, J., Asztély, F., Olofsdotter, K., Mohapel, P., Saarma, M., Lindvall, O., Kokaia, Z. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Suvanto, P., Wartiovaara, K., Lindahl, M., Arumae, U., Moshnyakov, M., Horelli-Kuitunen, N., Airaksinen, M.S., Palotie, A., Sariola, H., Saarma, M. Hum. Mol. Genet. (1997) [Pubmed]
  5. Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B., Olson, L. J. Neurosci. (1997) [Pubmed]
  6. GFRalpha 1 is required for development of distinct subpopulations of motoneuron. Garcès, A., Haase, G., Airaksinen, M.S., Livet, J., Filippi, P., deLapeyrière, O. J. Neurosci. (2000) [Pubmed]
  7. Transgene insertion induced dominant male sterility and rescue of male fertility using round spermatid injection. Meng, X., Akutsu, H., Schoene, K., Reifsteck, C., Fox, E.P., Olson, S., Sariola, H., Yanagimachi, R., Baetscher, M. Biol. Reprod. (2002) [Pubmed]
  8. Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Rossi, J., Tomac, A., Saarma, M., Airaksinen, M.S. Eur. J. Neurosci. (2000) [Pubmed]
  9. Identification of GFR alpha-2 isoforms in myenteric plexus of postnatal and adult rat intestine. Dolatshad, N.F., Silva, A.T., Saffrey, M.J. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  10. Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. Vargas-Leal, V., Bruno, R., Derfuss, T., Krumbholz, M., Hohlfeld, R., Meinl, E. J. Immunol. (2005) [Pubmed]
  11. GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2. Hiltunen, J.O., Laurikainen, A., Airaksinen, M.S., Saarma, M. Dev. Dyn. (2000) [Pubmed]
  12. Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. Nomoto, S., Ito, S., Yang, L.X., Kiuchi, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Neurotrophic factor receptor expression and in vitro nerve growth of geniculate ganglion neurons that supply divergent nerves. Yamout, A., Spec, A., Cosmano, J., Kashyap, M., Rochlin, M.W. Dev. Neurosci. (2005) [Pubmed]
  14. Quantification of mouse glial cell-line derived neurotrophic factor family receptor alpha 2 alternatively spliced isoforms by real time detection PCR using SYBR Green I. Wong, Y.W., Sia, G.M., Too, H.P. Neurosci. Lett. (2002) [Pubmed]
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