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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gstp2  -  glutathione S-transferase, pi 2

Mus musculus

Synonyms: GST YF-YF, GST class-pi, GST-piA, GSTpiA, Glutathione S-transferase P 2, ...
 
 
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High impact information on Gstp2

  • Amongst class Pi transferase subunits, the constitutive hepatic level of mRNA for Gstp1 and Gstp2 was not substantially affected in the KO mice, but their induction by BHA was dependent on Nrf2; this was more obvious in female mutant mice than in male mice [1].
  • This analysis together with computer graphics modeling for Gst p-2 indicated that these changes affected both substrate and glutathione binding to the enzyme [2].
  • Kinetic analysis of the wild-type and mutant enzymes revealed that the amino acid differences occurring at positions 10 (Val/Ser), 11 (Arg/Pro), and 104 (Val/Gly) are responsible for the reduced enzymatic activity of Gst p-2 [2].
  • In this report we have identified two actively transcribed murine Pi-class GST genes, Gst p-1 and Gst p-2 [3].
  • In addition to a TATA box and a sequence motif matching the phorbol-ester-responsive element, the promoters of Gst p-1 and Gst p-2 exhibit one and two G+C boxes (GGGCGG) respectively [3].
 

Biological context of Gstp2

References

  1. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Chanas, S.A., Jiang, Q., McMahon, M., McWalter, G.K., McLellan, L.I., Elcombe, C.R., Henderson, C.J., Wolf, C.R., Moffat, G.J., Itoh, K., Yamamoto, M., Hayes, J.D. Biochem. J. (2002) [Pubmed]
  2. Amino acid differences at positions 10, 11, and 104 explain the profound catalytic differences between two murine pi-class glutathione S-transferases. Bammler, T.K., Driessen, H., Finnstrom, N., Wolf, C.R. Biochemistry (1995) [Pubmed]
  3. Isolation and characterization of two mouse Pi-class glutathione S-transferase genes. Bammler, T.K., Smith, C.A., Wolf, C.R. Biochem. J. (1994) [Pubmed]
  4. Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus. Ejchel-Cohen, T.F., Wood, G.E., Wang, J.F., Barlow, K., Nobrega, J.N., S McEwen, B., Trevor Young, L. Brain Res. (2006) [Pubmed]
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