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Gene Review:

ORF40 - 6 copies form hexons, 5 copies form pentons

Human herpesvirus 3

Chee, M. et al., Lawrence, G.L. et al., Kennedy, P.G. et al.

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Disease relevance of ORF40

Identification of the major capsid protein gene of human cytomegalovirus [1].
The obtained antisera reacted in Western immunoblots with the MCP of purified HCMV virions [1].
In addition, the gene for the major capsid protein and its 5' neighbor are reoriented with respect to the spliced ORFs in the genomes of both HHV-6 and HCMV relative to the organization observed in EBV, HSV, and VZV [2].
However, the products of nine other ORFs are clearly homologous to a set of genes that is conserved in all other sequenced herpesviruses, including homologs of the alkaline exonuclease, the phosphotransferase, the spliced ORF, and the major capsid protein genes [2].
Three VZV probes from open reading frames 62, 16 and 40, which show homology with the Herpes Simplex Virus immediate early 175 kd protein, the 65 kd DNA binding protein and the major capsid protein respectively, were used for in situ hybridization studies in these VZV tissues [3].

High impact information on ORF40

The coding region for the major capsid protein (MCP) of human cytomegalovirus (HCMV) was identified by comparing the protein sequence with the respective sequences of herpes simplex virus (HSV), Epstein-Barr virus, and varicella-zoster virus [1].

References

Identification of the major capsid protein gene of human cytomegalovirus. Chee, M., Rudolph, S.A., Plachter, B., Barrell, B., Jahn, G. J. Virol. (1989) [Pubmed]
Human herpesvirus 6 is closely related to human cytomegalovirus. Lawrence, G.L., Chee, M., Craxton, M.A., Gompels, U.A., Honess, R.W., Barrell, B.G. J. Virol. (1990) [Pubmed]
Studies on the pathogenesis of neurological diseases associated with Varicella-Zoster virus. Kennedy, P.G., Barrass, J.D., Graham, D.I., Clements, G.B. Neuropathol. Appl. Neurobiol. (1990) [Pubmed]

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