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Gene Review

SLC30A7  -  solute carrier family 30 (zinc...

Homo sapiens

Synonyms: Solute carrier family 30 member 7, ZNT7, ZNTL2, Zinc transporter 7, ZnT-7, ...
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High impact information on SLC30A7

  • Furthermore, co-immunoprecipitation studies revealed that ZnT5 and ZnT6 formed hetero-oligomers, whereas ZnT7 formed homo-oligomers [1].
  • The inactive ALP protein in DT40 cells deficient in both ZnT5 and ZnT7 genes was transported to cytoplasmic membrane like the active ALP protein in the wild-type cells [2].
  • Combined disruptions of three transporter genes and re-expressions of transgenes revealed that ZnT5 and ZnT6 work in the same pathway, whereas ZnT7 acts alone [1].
  • We show that Znt7 is widely transcribed in mouse tissues with abundant expression in the liver and small intestine and moderate expression in the kidney, spleen, brain, and lung [3].
  • Interestingly, we found upregulation of ZnT7 transcripts in ESCC cells (TE13) grown in zinc deficient condition [4].

Anatomical context of SLC30A7


Analytical, diagnostic and therapeutic context of SLC30A7

  • Here, we characterized the cellular function of ZnT6 together with ZnT5 and ZnT7 by gene-targeting studies using DT40 cells [1].


  1. Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. Suzuki, T., Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2005) [Pubmed]
  2. Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2005) [Pubmed]
  3. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. Kirschke, C.P., Huang, L. J. Biol. Chem. (2003) [Pubmed]
  4. Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. Kumar, A., Chatopadhyay, T., Raziuddin, M., Ralhan, R. Int. J. Cancer (2007) [Pubmed]
  5. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Devergnas, S., Chimienti, F., Naud, N., Pennequin, A., Coquerel, Y., Chantegrel, J., Favier, A., Seve, M. Biochem. Pharmacol. (2004) [Pubmed]
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