Disease relevance of lef-7

• The predicted open reading frame of lef-7 from Bombyx mori nucleopolyhedrovirus (BmNPV) is 45 bp longer at the 5'-terminal and harbors a 42 bp deletion towards the 3' terminal end compared to that of Autograph californica mlulticapsid NPV (AcMNPV) [1].
• Identification of lef-7: a baculovirus gene affecting late gene expression [2].

High impact information on lef-7

• While sequencing the region of the AcMNPV genome containing lef-7, we also found a 215-codon open reading frame (ORF-215) approximately 1 kb downstream of lef-7 with sequence homology to eIF2 alpha kinases (e.g., rabbit eIF2 alpha and yeast GCN-2 kinase) [2].
• Therefore, the presumed initiation codon ATG (at 97059 nt of BmNPV genome) appears to be non-functional for lef-7 translation [1].

Biological context of lef-7

• The sequence of the predicted polypeptide product of this gene, lef-7, shared no obvious sequence homology to other sequences in available databases [2].

References