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Gene Review

G  -  glycoprotein

Infectious hematopoietic necrosis virus

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Disease relevance of G


High impact information on G


Chemical compound and disease context of G


Biological context of G

  • In contrast, fish injected with plasmids containing the N gene, G gene, or N + G gene mixture showed 70, 5, and 2.5% cumulative mortality, respectively [2].
  • Virus isolates belonging to the most common haplotype groups were distributed throughout Alaska, whereas isolates in small haplotype groups were obtained from only 1 site (hatchery, lake, etc.). The temporal pattern of the GF haplotypes suggested a 'genetic acclimation' of the G gene, possibly due to positive selection on the glycoprotein [9].
  • When transfection was performed in the presence of monoclonal antibodies (Mab) to the glycoprotein, the production of interferon mRNA transcripts was reduced by over 50% [10].

Anatomical context of G


Other interactions of G

  • The G and NV genes and their encoded proteins were highly conserved, with a maximum pairwise nucleotide divergence of 3.6 and 4.4%, and amino acid divergence of 3.7 and 6.2%, respectively [1].
  • Sequence analysis showed the presence of six open reading frames encoding the nucleoprotein N, the matrix proteins M1 and M2, the glycoprotein G, a so-called non-structural protein NV, and the RNA polymerase L. The genome organization is 3'N-M1-M2-G-NV-L 5'. The extreme 5' and 3' ends of the genome were sequenced after RNA ligation or RACE [6].

Analytical, diagnostic and therapeutic context of G

  • 1. The G protein expressed by transfected cells was detected by western blot analysis [2].
  • The efficiency of the anti-N system in detecting purified and crude viruses as well as the virus in infected-organ extracts and infected blood was compared with that of a recently described antigen capture ELISA based on the detection of viral envelope glycoprotein Gp (anti-G system) [11].
  • Genes encoding the nucleocapsid protein (N) and the C-terminal half of the glycoprotein (G) were amplified by RT-PCR and separately cloned into the eukaryotic expression vector pcDNA 3 [2].
  • The relative efficacy of various routes of immunisation with pIHNVw-G was evaluated using 1.8 g rainbow trout fry vaccinated via intramuscular injection, scarification of the skin, intraperitoneal injection, intrabuccal administration, cutaneous particle bombardment using a gene gun, or immersion in water containing DNA vaccine-coated beads [12].
  • Rainbow trout mother fish were inoculated against infectious haematopoietic necrosis virus (IHNV) by intraperitoneal injection of a fragment of the IHNV glycoprotein spanning amino acids 31 to 310 [13].


  1. Molecular epizootiology and evolution of the glycoprotein and non-virion protein genes of infectious hematopoietic necrosis virus, a fish rhabdovirus. Nichol, S.T., Rowe, J.E., Winton, J.R. Virus Res. (1995) [Pubmed]
  2. Protection of flounder against hirame rhabdovirus (HIRRV) with a DNA vaccine containing the glycoprotein gene. Seo, J.Y., Kim, K.H., Kim, S.G., Oh, M.J., Nam, S.W., Kim, Y.T., Choi, T.J. Vaccine (2006) [Pubmed]
  3. Expression of the glycoprotein gene from a fish rhabdovirus by using baculovirus vectors. Koener, J.F., Leong, J.A. J. Virol. (1990) [Pubmed]
  4. Epitope mapping and characterization of the infectious hematopoietic necrosis virus glycoprotein, using fusion proteins synthesized in Escherichia coli. Xu, L., Mourich, D.V., Engelking, H.M., Ristow, S., Arnzen, J., Leong, J.C. J. Virol. (1991) [Pubmed]
  5. Nucleotide sequence of the glycoprotein gene of viral haemorrhagic septicaemia (VHS) viruses from different geographical areas: a link between VHS in farmed fish species and viruses isolated from North Sea cod (Gadus morhua L.). Stone, D.M., Way, K., Dixon, P.F. J. Gen. Virol. (1997) [Pubmed]
  6. Complete genomic sequence of the fish rhabdovirus infectious haematopoietic necrosis virus. Schütze, H., Enzmann, P.J., Kuchling, R., Mundt, E., Niemann, H., Mettenleiter, T.C. J. Gen. Virol. (1995) [Pubmed]
  7. Phosphatidylserine binding to solid-phase rhabdoviral peptides: a new method to study phospholipid/viral protein interactions. Estepa, A., Coll, J.M. J. Virol. Methods (1996) [Pubmed]
  8. Naked DNA vaccination of Atlantic salmon Salmo salar against IHNV. Traxler, G.S., Anderson, E., LaPatra, S.E., Richard, J., Shewmaker, B., Kurath, G. Dis. Aquat. Org. (1999) [Pubmed]
  9. Genetic diversity and epidemiology of infectious hematopoietic necrosis virus in Alaska. Emmenegger, E.J., Meyers, T.R., Burton, T.O., Kurath, G. Dis. Aquat. Org. (2000) [Pubmed]
  10. Expression of the glycoprotein of viral haemorrhagic septicaemia virus (VHSV) on the surface of the fish cell line RTG-P1 induces type 1 interferon expression in neighbouring cells. Acosta, F., Collet, B., Lorenzen, N., Ellis, A.E. Fish Shellfish Immunol. (2006) [Pubmed]
  11. Highly sensitive immunoassay for direct diagnosis of viral hemorrhagic septicemia which uses antinucleocapsid monoclonal antibodies. Mourton, C., Romestand, B., de Kinkelin, P., Jeffroy, J., Le Gouvello, R., Pau, B. J. Clin. Microbiol. (1992) [Pubmed]
  12. Fish DNA vaccine against infectious hematopoietic necrosis virus: efficacy of various routes of immunisation. Corbeil, S., Kurath, G., LaPatra, S.E. Fish Shellfish Immunol. (2000) [Pubmed]
  13. Mother to fry, successful transfer of immunity against infectious haematopoietic necrosis virus infection in rainbow trout. Oshima, S., Hata, J., Segawa, C., Yamashita, S. J. Gen. Virol. (1996) [Pubmed]
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