High impact information on H2-T23

• This epitope is presented by the mouse H2-T23-encoded class Ib molecule Qa-1 and was recognized by CD8+ cytotoxic T lymphocytes induced after natural infection [1].
• Analysis of regulatory CD8 T cells in Qa-1-deficient mice [2].
• We report that transfection of a mouse fibroblast line with gene T23b leads to the surface expression of a molecule that is structurally identical to lymphocyte Qa-1b [3].
• These observations suggest that the Qa-1 molecule may be involved in the presentation of heat shock protein-derived peptides to the immune system [3].
• Qdm is the dominant peptide loaded onto Qa-1 under physiological conditions and this peptide has an optimal sequence for binding to Qa-1 [4].

Biological context of H2-T23

• Recent data have suggested that the class Ib molecule Qa-1 may be involved in antigen presentation to T cells expressing gamma delta receptors [3].

Anatomical context of H2-T23

• Constitutive and regulated expression of the class IB molecule Qa-1 in pancreatic beta cells [5].

Associations of H2-T23 with chemical compounds

• Correlate experiments performed in C5-deficient (B10.D2-H2d H2-T18c Hco/oSnJ) mice revealed similar results, leading to the conclusion that C5 plays a significant role in mediation of chemotactic and activation events that are the basis for maturation of granulomatous responses to TDM [6].

Other interactions of H2-T23

• One exhibited highest similarity to an H2 class I b gene, H2-T23 (encoding the Qa1 antigen) [7].

Analytical, diagnostic and therapeutic context of H2-T23

• We compared the expression of Qa-1 and MHC class IA in a beta-cell line (beta TC6-F7) before and after treatment with the insulitic cytokine interferon-gamma (IFN-gamma) [5].

References