The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

H2-Q1  -  histocompatibility 2, Q region locus 1

Mus musculus

Synonyms: 15006, H-2Q1, Q1, Q1b, Q1d, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of H2-Q1


High impact information on H2-Q1

  • Both Ld and Qsm can interact with Qa-1 to form cell surface-expressed heterodimers in vivo [3].
  • These interactions may enable increased levels of Qa-1 to reach the cell surface and may subsequently influence T cell recognition of Qa-1 and/or Ld molecules [3].
  • Furthers analyses of a panel of recombinants revealed that the 50-kD protein coprecipitated with Qa-1 in H-2b haplotype mouse strains is encoded or controlled by a gene centromeric to major histocompatibility complex class II I-E beta [3].
  • These Qa-1 heterodimers are not expressed in H-2k haplotype cells [3].
  • The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E beta [3].

Biological context of H2-Q1

  • The class I gene RT1.46 (l) has an open reading frame, but it is unlike H2-D due to a unique 5'UTR shared with H2-Q1 and Q2, the absence of the B2 SINE repeat characteristic of H2-D/L, and the apparent lack of surface expression [4].
  • Restriction maps of overlapping lambda and cosmid clones reveal that there are only five Qak genes: Q1k, Q2k, Q4k, Q10k and a Q5/9 hybrid, presumably generated by unequal homologous recombination [5].
  • TCDD-induced down-regulation of MHC Q1b requires both the aromatic hydrocarbon receptor and the aromatic hydrocarbon receptor nuclear translocator, transcription factors that up-regulate other genes in response to TCDD [6].
  • Each of the four common Qa-1 phenotypes was shown to exhibit unique antigenic determinants [7].
  • The nature of cell surface determinants detected by Qa-1-specific alloantisera and cytotoxic T lymphocytes (CTL) in mice of the H-2f, Qa-1d genotype was investigated [8].

Anatomical context of H2-Q1

  • Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire: definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity with H-2 [7].
  • Analysis of Qa-1 isolated from detergent lysates of surface labeled cells indicated this molecule was a slightly acidic 48,000 to 50,000 dalton glycoprotein that displayed little charge heterogeneity on resting lymphocytes [9].
  • Listeria-infected bone marrow macrophages from congenic and recombinant strains of mice were lysed only when they shared the H2-T region or were Qa1-compatible with the immune cytotoxic cells; sharing of the H2-D, Q, or M region was insufficient [10].
  • Cytotoxic T lymphocytes (CTL) activated in H-2 identical, Qa-1 disparate mixed leukocyte cultures recognize H-2-nonrestricted target antigens indistinguishable by strain or tissue distribution from serologically defined Qa-1 antigens [11].
  • Fetal NK cells lacking receptors for Qa1 (and also for classical class I molecules) cannot distinguish between wild-type and class I-deficient blasts but, surprisingly, distinguish efficiently between certain wild-type and class I-deficient tumor cells [12].

Associations of H2-Q1 with chemical compounds


Other interactions of H2-Q1

  • The Qa-1/Ld and Qa-1/Qsm heterodimers are associated by noncovalent interactions and occur only between fully processed proteins [3].
  • One exhibited highest similarity to an H2 class I b gene, H2-T23 (encoding the Qa1 antigen) [14].
  • In the present study we describe an in vivo model of antigen-specific transplantation tolerance to skin allografts using mice congenic at Qa1, a ubiquitously expressed class I-like molecule encoded to the right of H-2D [15].
  • The Qed-1 locus was mapped distal to Qa-2 [16].
  • One of the Pema class I cDNA clones classified as H2-K, D/L-like (class I a) is predicted to encode an identical peptide, implying that an antigen binding protein (Qa1) and the antigen to which it binds (the product of Qdm) has been conserved for over 50 My [14].

Analytical, diagnostic and therapeutic context of H2-Q1

  • A candidate peptide-binding motif was determined by sequence analysis of peptides eluted from Qa-1 that had been folded in the presence of random peptide libraries or pools of Qdm derivatives randomized at specific anchor positions [17].
  • Peptide mapping analysis also demonstrated that the Tlaa and Qa-1a allelic products were distinct from one another, as well as being very different from the other three Qa-1 allelic products [9].
  • Expression of Qa-1 protein was assessed on ocular frozen tissue sections by immunohistochemistry, and within aqueous humor by western blotting [18].


  1. H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Ugrinovic, S., Brooks, C.G., Robson, J., Blacklaws, B.A., Hormaeche, C.E., Robinson, J.H. Infect. Immun. (2005) [Pubmed]
  2. Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. Panoutsakopoulou, V., Huster, K.M., McCarty, N., Feinberg, E., Wang, R., Wucherpfennig, K.W., Cantor, H. J. Clin. Invest. (2004) [Pubmed]
  3. The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E beta. Wolf, P.R., Cook, R.G. J. Exp. Med. (1995) [Pubmed]
  4. Does the rat have an H2-D orthologue next to Bat1? Lambracht-Washington, D., Fischer Lindahl, K. Immunogenetics (2002) [Pubmed]
  5. Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution. Watts, S., Davis, A.C., Gaut, B., Wheeler, C., Hill, L., Goodenow, R.S. EMBO J. (1989) [Pubmed]
  6. Down-regulation of major histocompatibility complex Q1b gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Dong, L., Ma, Q., Whitlock, J.P. J. Biol. Chem. (1997) [Pubmed]
  7. Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire: definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity with H-2. Aldrich, C.J., Jenkins, R.N., Rich, R.R. J. Immunol. (1986) [Pubmed]
  8. The Qa-1 alloantigens. II. Evidence for the expression of two Qa-1 molecules by the Qa-1d genotype and for cross-reactivity between Qa-1 and H-2K. Cook, R.G., Jenkins, R.N., Flaherty, L., Rich, R.R. J. Immunol. (1983) [Pubmed]
  9. The Qa-1 alloantigens. III. Biochemical analysis of the structure and extent of polymorphism of the Qa-1 allelic products. Landolfi, N.F., Rich, R.R., Cook, R.G. J. Immunol. (1985) [Pubmed]
  10. An H2-T MHC class Ib molecule presents Listeria monocytogenes-derived antigen to immune CD8+ cytotoxic T cells. Bouwer, H.G., Lindahl, K.F., Baldridge, J.R., Wagner, C.R., Barry, R.A., Hinrichs, D.J. J. Immunol. (1994) [Pubmed]
  11. Correlation of Qa-1 determinants defined by antisera and by cytotoxic T lymphocytes. Jenkins, R.N., Aldrich, C.J., Landolfi, N.F., Rich, R.R. Immunogenetics (1985) [Pubmed]
  12. Stochastic acquisition of Qa1 receptors during the development of fetal NK cells in vitro accounts in part but not in whole for the ability of these cells to distinguish between class I-sufficient and class I-deficient targets. Toomey, J.A., Salcedo, M., Cotterill, L.A., Millrain, M.M., Chrzanowska-Lightowlers, Z., Lawry, J., Fraser, K., Gays, F., Robinson, J.H., Shrestha, S., Dyson, P.J., Brooks, C.G. J. Immunol. (1999) [Pubmed]
  13. Functional analysis of the molecular factors controlling Qa1-mediated protection of target cells from NK lysis. Gays, F., Fraser, K.P., Toomey, J.A., Diamond, A.G., Millrain, M.M., Dyson, P.J., Brooks, C.G. J. Immunol. (2001) [Pubmed]
  14. Expressed Peromyscus maniculatus (Pema) MHC class I genes: evolutionary implications and the identification of a gene encoding a Qa1-like antigen. Crew, M.D., Bates, L.M., Douglass, C.A., York, J.L. Immunogenetics (1996) [Pubmed]
  15. In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help. Rees, M.A., Rosenberg, A.S., Munitz, T.I., Singer, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  16. Qed-1--a target for unrestricted killing by T cells. Lindahl, K.F., Hausmann, B. Eur. J. Immunol. (1980) [Pubmed]
  17. Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. Kraft, J.R., Vance, R.E., Pohl, J., Martin, A.M., Raulet, D.H., Jensen, P.E. J. Exp. Med. (2000) [Pubmed]
  18. Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye. Kim, C.Y., Masli, S., Streilein, J.W. Ocul. Immunol. Inflamm. (2005) [Pubmed]
WikiGenes - Universities