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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hbb-y  -  hemoglobin Y, beta-like embryonic chain

Mus musculus

Synonyms: Epsilon-Y2-globin, Ey, Hby, Hemoglobin epsilon-Y2 chain, Hemoglobin subunit epsilon-Y2, ...
 
 
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High impact information on Hbb-y

  • Replacement of 5'HS2 with a selectable marker gene (delta HS2 + neo) causes a 2-5-fold reduction in expression of all of the genes in the locus, and a more pronounced effect (10-12-fold) on the most 5' embryonic globin gene, Ey, when expression of this gene is first detectable during embryogenesis [1].
  • A restriction fragment size difference of 1.9 kilobases exists between the C57BL/10 (Hbbs) and BALB/c (Hbbd) beta-globin gene clusters in the vicinity of the Hbb-y and Hbb-bh0 genes [2].
  • We found that Gata4-/- embryoid bodies, grown either in suspension culture or attached to a substratum, are defective in primitive hematopoiesis and vasculogenesis as evidenced by a lack of recognizable blood islands and vascular channels and a reduction in the expression of the primitive erythrocyte marker epsilon y-globin [3].
  • The nucleotide sequence of pFG5 confirms that it does not code for the beta major or beta minor globin chains nor the embryonic epsilon Y2 globin chain; but it is identical to the published partial sequence of the epsilon Y3 globin gene over the region of overlap (78 nucleotides) [4].
  • The embryonic beta-globin genes Ey and betaH1 are located in a approximately 30 kb central subdomain characterized by low-level histone acetylation, while the fetal/adult genes betamajor and betaminor and the upstream locus control region reside in hyperacetylated chromatin [5].
 

Biological context of Hbb-y

  • Using a reporter system consisting of a human gamma-globin promoter driving the neomycin phosphotransferase gene (gamma-neo), we tested murine LCR fragments extending from -21 to -9 kb (with respect to the epsilon y-globin gene cap site) for activity in classical enhancer and integration site assays in K562 and MEL cells [6].
 

Anatomical context of Hbb-y

  • Isolation and characterization of cDNA encoding chicken egg yolk aminopeptidase Ey [7].
 

Other interactions of Hbb-y

  • The murine homologue of 5' HS-3 is located approximately 16.0 kb upstream from the mouse epsilon y-globin gene, but no region homologous to human 5' HS-4 was present in our clone [6].

References

  1. Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Fiering, S., Epner, E., Robinson, K., Zhuang, Y., Telling, A., Hu, M., Martin, D.I., Enver, T., Ley, T.J., Groudine, M. Genes Dev. (1995) [Pubmed]
  2. A naturally occurring deletion in the mouse Hbbs beta-globin gene cluster. Holdener-Kenny, B., Weaver, S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm. Bielinska, M., Narita, N., Heikinheimo, M., Porter, S.B., Wilson, D.B. Blood (1996) [Pubmed]
  4. Cloning of a new mouse foetal beta-globin mRNA sequence. Affara, N.A., Goldfarb, P.S., Vass, K., Lyons, A., Harrison, P.R. Nucleic Acids Res. (1981) [Pubmed]
  5. Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. Im, H., Grass, J.A., Christensen, H.M., Perkins, A., Bresnick, E.H. Biochemistry (2002) [Pubmed]
  6. Structure and function of the murine beta-globin locus control region 5' HS-3. Hug, B.A., Moon, A.M., Ley, T.J. Nucleic Acids Res. (1992) [Pubmed]
  7. Isolation and characterization of cDNA encoding chicken egg yolk aminopeptidase Ey. Midorikawa, T., Abe, R., Yamagata, Y., Nakajima, T., Ichishima, E. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
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