The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Hbb-b2  -  hemoglobin, beta adult minor chain

Mus musculus

Synonyms: AI036344, Beta-2-globin, Hbb2, Hbbt2, Hemoglobin beta-2 chain, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hbb-b2


High impact information on Hbb-b2

  • Here we report a 16-kb deletion that includes both adult beta-like globin genes, beta maj and beta min, in mouse embryonic stem cells [3].
  • The marked beta-major gene can be tracked at the level of DNA, RNA, and protein, allowing investigation of the impact of a retained phosphoglycerate kinase (PGK)-neo cassette located between the mutant beta-major and beta-minor globin genes on expression of these 2 neighboring genes [4].
  • Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes [4].
  • A 1-year follow-up of 12 treated animals showed a stable correction of anemia associated with improved RBC morphology, increased beta-minor globin synthesis, and decreased amounts of alpha-globin chains bound to erythrocyte membranes [5].
  • This study indicates that the continuous delivery of high amounts of autologous erythropoietin induced a sustained stimulation of beta-minor globin synthesis and a stable improvement of erythropoiesis in the beta-thalassemic mouse model [5].

Chemical compound and disease context of Hbb-b2


Biological context of Hbb-b2

  • In Hbb-b1 cDNA, six base substitutions were found between the d and w1 haplotypes and also between p and w1, but none existed between d and p. In Hbb-b2 cDNA, three base substitutions were found between the d and w1 haplotypes and also between d and p, but none between p and w1 [8].
  • beta-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice [9].
  • Transfected intact mouse alpha 1-globin genes generate transcripts, whereas beta maj and beta min globin transcripts are detected only if the genes are associated with a strong exogenous (SV40) enhancer sequence [2].
  • In normal mice, dysregulated Epo production induced elevated serum Epo levels (176 +/- 68 mU/mL), high hematocrit levels (73% +/- 8%), and elevated beta-minor globin chain synthesis [10].
  • Transcription from the beta major and beta minor globin genes was measured separately by hybridization to cloned DNA sequences from a region of the second intron which is highly divergent in the two genes [11].

Anatomical context of Hbb-b2


Associations of Hbb-b2 with chemical compounds


Other interactions of Hbb-b2


  1. Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control. Curcio, M.J., Kantoff, P., Schafer, M.P., Anderson, W.F., Safer, B. J. Biol. Chem. (1986) [Pubmed]
  2. Regulation of murine alpha-, beta major-, and beta minor-globin gene expression. Weich, N., Marks, P.A., Rifkind, R.A. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  3. Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Ciavatta, D.J., Ryan, T.M., Farmer, S.C., Townes, T.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. Kaufman, R.M., Lu, Z.H., Behl, R., Holt, J.M., Ackers, G.K., Ley, T.J. Blood (2001) [Pubmed]
  5. Improvement of erythropoiesis in beta-thalassemic mice by continuous erythropoietin delivery from muscle. Bohl, D., Bosch, A., Cardona, A., Salvetti, A., Heard, J.M. Blood (2000) [Pubmed]
  6. The beta major and beta minor globin nuclear transcripts of Friend erythroleukemia cells induced to differentiate in culture. Curtis, P., Finnigan, A.C., Rovera, G. J. Biol. Chem. (1980) [Pubmed]
  7. Nuclear precursor molecules of the two beta-globin mRNAs in Friend erythroleukemia cells. Donaldson, D.S., McNab, A.R., Rovera, G., Curtis, P.J. J. Biol. Chem. (1982) [Pubmed]
  8. Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). Ueda, Y., Miyashita, N., Imai, K., Yamaguchi, Y., Takamura, K., Notohara, M., Shiroishi, T., Kawashima, T., Ning, L., Wang, C., Wu, X., Moriwaki, K. Mamm. Genome (1999) [Pubmed]
  9. beta-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice. Porcu, S., Poddie, D., Melis, M., Cao, A., Ristaldi, M.S. Gene (2005) [Pubmed]
  10. Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia. Villeval, J.L., Rouyer-Fessard, P., Blumenfeld, N., Henri, A., Vainchenker, W., Beuzard, Y. Blood (1994) [Pubmed]
  11. Absolute rates of globin gene transcription and mRNA formation during differentiation of cultured mouse erythroleukemia cells. Ganguly, S., Skoultchi, A.I. J. Biol. Chem. (1985) [Pubmed]
  12. The beta-major and beta-minor globin genes in murine erythroleukemia cells replicate during the same early interval of the S phase. Braunstein, J.D., Schildkraut, C.L. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  13. Mechanisms leading to sustained reversion of beta-thalassemia in mice by doxycycline-controlled Epo delivery from muscles. Samakoglu, S., Bohl, D., Heard, J.M. Mol. Ther. (2002) [Pubmed]
  14. Variable globin chain synthesis in mouse erythroleukemia cells. Alter, B.P., Goff, S.C. Blood (1978) [Pubmed]
  15. The molecular organization of the beta-globin complex of the deer mouse, Peromyscus maniculatus. Padgett, R.W., Loeb, D.D., Snyder, L.R., Edgell, M.H., Hutchison, C.A. Mol. Biol. Evol. (1987) [Pubmed]
  16. Hexamethylenebisacetamide-mediated induction of murine erythroleukemia cells: relationship between expression of beta major and beta minor globin genes, globin mRNA synthesis and commitment to erythroid differentiation. Gambari, R. Biochem. Int. (1983) [Pubmed]
WikiGenes - Universities