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DTX3L  -  deltex 3 like, E3 ubiquitin ligase

Homo sapiens

Synonyms: B-lymphoma-and BAL-associated protein, BBAP, E3 ubiquitin-protein ligase DTX3L, Protein deltex-3-like, Rhysin-2, ...
 
 
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Disease relevance of DTX3L

  • BAL1 and BBAP were most abundant in lymphomas with a brisk host inflammatory response, designated host response (HR) tumors [1].
 

High impact information on DTX3L

  • Although these DLBCLs include significant numbers of tumor-infiltrating lymphocytes and interdigitating dendritic cells, BAL1 and BBAP were expressed primarily by malignant B cells, prompting speculation that the genes might be induced by host-derived inflammatory mediators such as gamma interferon (IFN-gamma) [1].
  • We show that BAL1 and BBAP are located on chromosome 3q21 in a head-to-head orientation and are regulated by a IFN-gamma-responsive bidirectional promoter [1].
  • Consistent with this idea, BBAP and DTX1 associate via their unique N termini, resulting in enhanced self-ubiquitination [2].
  • Using a yeast two-hybrid screen for BAL-binding partners, we have now identified a novel protein termed BBAP (B-lymphoma- and BAL-associated protein) [2].
 

Anatomical context of DTX3L

  • BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate [1].

References

  1. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Juszczynski, P., Kutok, J.L., Li, C., Mitra, J., Aguiar, R.C., Shipp, M.A. Mol. Cell. Biol. (2006) [Pubmed]
  2. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. Takeyama, K., Aguiar, R.C., Gu, L., He, C., Freeman, G.J., Kutok, J.L., Aster, J.C., Shipp, M.A. J. Biol. Chem. (2003) [Pubmed]
 
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