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Gene Review

Hdac6  -  histone deacetylase 6

Mus musculus

Synonyms: HD6, Hd6, Hdac5, Histone deacetylase 6, Histone deacetylase mHDA2, ...
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High impact information on Hdac6

  • Only one of the two catalytic domains of HDAC6 possesses tubulin deacetylase activity, and only this domain is bound by tubacin [1].
  • HDAC6 overexpression disrupted the localization of p58, a protein that mediates binding of Golgi elements to microtubules [1].
  • Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways [2].
  • In contrast, HNP-4 and HD6 bound heparan sulfate, but not gB [3].
  • Besides the tetradecapeptide repeat domain, human HDAC6 possesses two LMB-sensitive nuclear export signals and a nuclear localization signal [4].

Biological context of Hdac6


Anatomical context of Hdac6

  • Only four of the hybridomas (R2-DA10/F7, R2-GE7/H2, R2-HC2/A5, R2-HD6/F7) produced Abs crossreactive with the transition-state analog [6].

Associations of Hdac6 with chemical compounds

  • Moreover, it forms a unique structure and is required for the LMB-resistant cytoplasmic localization of human HDAC6 [4].
  • Related to this structural difference, the cytoplasmic localization of human, but not murine, HDAC6 is resistant to treatment with leptomycin B (LMB) [4].

Other interactions of Hdac6

  • Interestingly, one, mHDA2, encodes a protein with two putative deacetylase domains, and the other, mHDA1, contains only one deacetylase homology domain, located at the C-terminal half of the protein [5].


  1. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Haggarty, S.J., Koeller, K.M., Wong, J.C., Grozinger, C.M., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Seigneurin-Berny, D., Verdel, A., Curtet, S., Lemercier, C., Garin, J., Rousseaux, S., Khochbin, S. Mol. Cell. Biol. (2001) [Pubmed]
  3. Human {alpha}- and beta-Defensins Block Multiple Steps in Herpes Simplex Virus Infection. Hazrati, E., Galen, B., Lu, W., Wang, W., Ouyang, Y., Keller, M.J., Lehrer, R.I., Herold, B.C. J. Immunol. (2006) [Pubmed]
  4. Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention. Bertos, N.R., Gilquin, B., Chan, G.K., Yen, T.J., Khochbin, S., Yang, X.J. J. Biol. Chem. (2004) [Pubmed]
  5. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. Verdel, A., Khochbin, S. J. Biol. Chem. (1999) [Pubmed]
  6. Production and characterization of monoclonal antibodies against urea derivatives. Rohde, M., Schenk, J.A., Heymann, S., Behrsing, O., Scharte, G., Kempter, G., Woller, J., Höhne, W.E., Warsinke, A., Micheel, B. Appl. Biochem. Biotechnol. (1998) [Pubmed]
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