High impact information on Hdac6

• Only one of the two catalytic domains of HDAC6 possesses tubulin deacetylase activity, and only this domain is bound by tubacin [1].
• HDAC6 overexpression disrupted the localization of p58, a protein that mediates binding of Golgi elements to microtubules [1].
• Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways [2].
• In contrast, HNP-4 and HD6 bound heparan sulfate, but not gB [3].
• Besides the tetradecapeptide repeat domain, human HDAC6 possesses two LMB-sensitive nuclear export signals and a nuclear localization signal [4].

Biological context of Hdac6

• Moreover, like histone H1(0) gene, mHDA1 and mHDA2 gene expression is induced upon deacetylase inhibitor treatment [5].

Anatomical context of Hdac6

• Only four of the hybridomas (R2-DA10/F7, R2-GE7/H2, R2-HC2/A5, R2-HD6/F7) produced Abs crossreactive with the transition-state analog [6].

Associations of Hdac6 with chemical compounds

• Moreover, it forms a unique structure and is required for the LMB-resistant cytoplasmic localization of human HDAC6 [4].
• Related to this structural difference, the cytoplasmic localization of human, but not murine, HDAC6 is resistant to treatment with leptomycin B (LMB) [4].

Other interactions of Hdac6

• Interestingly, one, mHDA2, encodes a protein with two putative deacetylase domains, and the other, mHDA1, contains only one deacetylase homology domain, located at the C-terminal half of the protein [5].

References