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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hoxa6  -  homeobox A6

Mus musculus

Synonyms: Homeobox protein Hox-1.2, Homeobox protein Hox-A6, Homeobox protein M5-4, Hox-1.2, Hoxa-6
 
 
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Disease relevance of Hoxa6

  • Of all common integration sites, a small region of 19 kb in the Hoxa gene locus, mostly between Hoxa6 and Hoxa10, represented 18% of all integrations in the E2a-PBX1 B-cell leukemia and was targeted in 86% of these leukemias compared to 17% in control tumors [1].
 

High impact information on Hoxa6

 

Biological context of Hoxa6

  • The specific localization of Hox 1.2 and Hox 1.4 transcripts in the embryonic CNS and the restricted pattern of expression along the rostrocaudal axis are strikingly reminiscent of the expression pattern of Drosophila homeoboxes in the fly embryo and larvae [2].
 

Anatomical context of Hoxa6

References

  1. High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Bijl, J., Sauvageau, M., Thompson, A., Sauvageau, G. Genes Dev. (2005) [Pubmed]
  2. Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system. Toth, L.E., Slawin, K.L., Pintar, J.E., Nguyen-Huu, M.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  3. Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Kostic, D., Capecchi, M.R. Mech. Dev. (1994) [Pubmed]
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