The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hoxa4  -  homeobox A4

Mus musculus

Synonyms: AV206827, Homeobox protein Hox-1.4, Homeobox protein Hox-A4, Homeobox protein MH-3, Hox-1.4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hoxa4


High impact information on Hoxa4


Biological context of Hoxa4


Anatomical context of Hoxa4

  • Hoxa4 is not expressed in hair follicles after P4 [13].
  • Disruption of the adjacent Hoxa4 gene leads to similar homeotic transformations of the cervicothoracic vertebrae [12].
  • Hoxa4 expression is first seen in E13.5 vibrissae throughout the follicle placode [13].
  • We next analyzed the expression of several of the Hox-1.4 orthologues in the mouse testis to determine if other members of the Hox-1 cluster are involved in the male germ cell differentiation pathway [14].
  • In the midgestation fetus, Hox-1.4 expression is most abundant in the spinal cord [1].

Associations of Hoxa4 with chemical compounds


Physical interactions of Hoxa4


Other interactions of Hoxa4

  • When administered to Hoxa4 null embryos, however, persistent ectopic expression was not observed, suggesting that autoregulation is required for maintenance of the retinoic acid-induced expression [9].
  • A possible correlation between the structural organization of homeobox-containing genes and their cell-specific expression was examined in studies determining similarities and differences in the expression patterns of orthologues and paralogues of the murine Hox-1.4 gene [14].
  • Thus, MLL-ENL is required to initiate and maintain immortalization of myeloid progenitors and may contribute to leukemogenesis by aberrantly sustaining the expression of a "Hox code" consisting of Hoxa4 to Hoxa11 [16].
  • In contrast, Hox-1.4 and Hox-2.6 transcripts were relatively weakly detected at 8 1/2 and 9 1/2 days, but were abundant within the lung and stomach at 12 1/2 days [17].
  • Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes [18].

Analytical, diagnostic and therapeutic context of Hoxa4

  • Sequence analysis of a Hoxa4-Hoxa5 intergenic region including shared regulatory elements [19].
  • The use of truncated mutant Hoxa-4 proteins in gel retardation assays and in transient co-transfection experiments revealed that the intact homeodomain was required for the binding [4].


  1. Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development. Wolgemuth, D.J., Viviano, C.M., Gizang-Ginsberg, E., Frohman, M.A., Joyner, A.L., Martin, G.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene. Tennyson, V.M., Gershon, M.D., Sherman, D.L., Behringer, R.R., Raz, R., Crotty, D.A., Wolgemuth, D.J. Dev. Dyn. (1993) [Pubmed]
  3. Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 gene. Tennyson, V.M., Gershon, M.D., Wade, P.R., Crotty, D.A., Wolgemuth, D.J. Dev. Dyn. (1998) [Pubmed]
  4. Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron. Wu, K., Wolgemuth, D.J. J. Cell. Biochem. (1993) [Pubmed]
  5. Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development. Wolgemuth, D.J., Behringer, R.R., Mostoller, M.P., Brinster, R.L., Palmiter, R.D. Nature (1989) [Pubmed]
  6. A mouse homeo box gene is expressed in spermatocytes and embryos. Rubin, M.R., Toth, L.E., Patel, M.D., D'Eustachio, P., Nguyen-Huu, M.C. Science (1986) [Pubmed]
  7. Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code. Pitera, J.E., Smith, V.V., Thorogood, P., Milla, P.J. Gastroenterology (1999) [Pubmed]
  8. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Heller, R.S., Stoffers, D.A., Hussain, M.A., Miller, C.P., Habener, J.F. Gastroenterology (1998) [Pubmed]
  9. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Packer, A.I., Crotty, D.A., Elwell, V.A., Wolgemuth, D.J. Development (1998) [Pubmed]
  10. Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes. Manzanares, M., Cordes, S., Ariza-McNaughton, L., Sadl, V., Maruthainar, K., Barsh, G., Krumlauf, R. Development (1999) [Pubmed]
  11. HOXD4 and regulation of the group 4 paralog genes. Morrison, A., Ariza-McNaughton, L., Gould, A., Featherstone, M., Krumlauf, R. Development (1997) [Pubmed]
  12. Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton. Aubin, J., Lemieux, M., Tremblay, M., Behringer, R.R., Jeannotte, L. Dev. Dyn. (1998) [Pubmed]
  13. Hoxa4 expression in developing mouse hair follicles and skin. Packer, A.I., Jane-Wit, D., McLean, L., Panteleyev, A.A., Christiano, A.M., Wolgemuth, D.J. Mech. Dev. (2000) [Pubmed]
  14. Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene. Watrin, F., Wolgemuth, D.J. Dev. Biol. (1993) [Pubmed]
  15. The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene. Chavrier, P., Vesque, C., Galliot, B., Vigneron, M., Dollé, P., Duboule, D., Charnay, P. EMBO J. (1990) [Pubmed]
  16. Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells. Horton, S.J., Grier, D.G., McGonigle, G.J., Thompson, A., Morrow, M., De Silva, I., Moulding, D.A., Kioussis, D., Lappin, T.R., Brady, H.J., Williams, O. Cancer Res. (2005) [Pubmed]
  17. Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation. Gaunt, S.J., Krumlauf, R., Duboule, D. Development (1989) [Pubmed]
  18. Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Zhao, Y., Potter, S.S. Dev. Biol. (2002) [Pubmed]
  19. Sequence analysis of a Hoxa4-Hoxa5 intergenic region including shared regulatory elements. Moreau, J., Jeannotte, L. DNA Seq. (2002) [Pubmed]
WikiGenes - Universities