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Gene Review

Hoxa10  -  homeobox A10

Mus musculus

Synonyms: Homeobox protein Hox-1.8, Homeobox protein Hox-A10, Hox-1.8, Hoxa-10
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Disease relevance of Hoxa10


High impact information on Hoxa10

  • We show here that expression of Hoxa10 in the presomitic mesoderm is sufficient to confer a Hox group 10 patterning program to the somite, producing vertebrae without ribs, an effect not achieved when Hoxa10 is expressed in the somites [5].
  • Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice [6].
  • In competitive transplantation assays, Hoxa-9-/- cells showed an 8-fold reduction in multilineage long-term repopulating ability, a defect not seen in marrow cells deficient for the adjacent Hoxa-10 gene [7].
  • Finally, a binding site selection identified the sequence AA(A/T)TTTTATTAC as the Hoxa-10 homeodomain consensus binding site, with a TTAT core sequence [8].
  • Both Hoxa-10 transcripts demonstrated identical patterns of expression in the posterior body and proximal limb bud, differentiating them from AbdB morphogenetic and regulatory transcripts and suggesting a role with other AbdB Hox genes in the patterning of these structures [8].

Biological context of Hoxa10


Anatomical context of Hoxa10


Associations of Hoxa10 with chemical compounds


Regulatory relationships of Hoxa10

  • Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse [2].
  • Hoxa-10 influences a host of uterine genes and natural killer cell function during appropriate development of regional decidualization at the site of implantation [16]
  • Hoxa-10 signaling controls two opposing cell cycle regulators: cyclin D3 (a key factor that promotes cell proliferation) [17] and cyclin G1 (a factor that inhibits cell proliferation) [18] in the uterus during early pregnancy.

Other interactions of Hoxa10

  • These observations suggest that Hoxa10 and Hoxd10 coordinately regulate skeletal development and innervation of the hindlimb [12].
  • MATERIALS AND METHODS: Hoxa10 and Gnrhr deficient mice were intercrossed with Insl3 transgenic mice [1].
  • RESULTS: Transgenic over expression of Insl3 failed to restore normal testicular descent in Hoxa10 or Gnrhr deficient males [1].
  • Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation [19].
  • Expression and gene targeting studies have shown that leukemia inhibitory factor (LIF), a cytokine of the IL-6 family, and Hoxa-10, an abdominalB-like homeobox gene, are crucial to implantation and decidualization in mice [19].

Analytical, diagnostic and therapeutic context of Hoxa10




  1. Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice. Feng, S., Bogatcheva, N.V., Truong, A., Engel, W., Adham, I.M., Agoulnik, A.I. J. Urol. (2006) [Pubmed]
  2. Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Lim, H., Ma, L., Ma, W.G., Maas, R.L., Dey, S.K. Mol. Endocrinol. (1999) [Pubmed]
  3. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Bagot, C.N., Troy, P.J., Taylor, H.S. Gene Ther. (2000) [Pubmed]
  4. Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor. Sarno, J.L., Schatz, F., Lockwood, C.J., Huang, S.T., Taylor, H.S. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  5. Hox genes specify vertebral types in the presomitic mesoderm. Carapuço, M., Nóvoa, A., Bobola, N., Mallo, M. Genes Dev. (2005) [Pubmed]
  6. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. Rijli, F.M., Matyas, R., Pellegrini, M., Dierich, A., Gruss, P., Dollé, P., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Lawrence, H.J., Christensen, J., Fong, S., Hu, Y.L., Weissman, I., Sauvageau, G., Humphries, R.K., Largman, C. Blood (2005) [Pubmed]
  8. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Benson, G.V., Nguyen, T.H., Maas, R.L. Mol. Cell. Biol. (1995) [Pubmed]
  9. Regulation of smooth muscle-specific gene expression by homeodomain proteins, Hoxa10 and Hoxb8. El-Mounayri, O., Triplett, J.W., Yates, C.W., Herring, B.P. J. Biol. Chem. (2005) [Pubmed]
  10. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Daikoku, T., Tranguch, S., Friedman, D.B., Das, S.K., Smith, D.F., Dey, S.K. Mol. Endocrinol. (2005) [Pubmed]
  11. Pleiotropic effects of Hoxa10 on the functional development of peri-implantation endometrium. Daftary, G.S., Taylor, H.S. Mol. Reprod. Dev. (2004) [Pubmed]
  12. The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Wahba, G.M., Hostikka, S.L., Carpenter, E.M. Dev. Biol. (2001) [Pubmed]
  13. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Hedlund, E., Karsten, S.L., Kudo, L., Geschwind, D.H., Carpenter, E.M. J. Neurosci. Res. (2004) [Pubmed]
  14. Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning. Lin, A.W., Carpenter, E.M. J. Neurobiol. (2003) [Pubmed]
  15. Methoxychlor disrupts uterine Hoxa10 gene expression. Fei, X., Chung, H., Taylor, H.S. Endocrinology (2005) [Pubmed]
  16. Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization. Rahman, M.A., Li, M., Li, P., Wang, H., Dey, S.K., Das, S.K. Dev. Biol. (2006) [Pubmed]
  17. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. Das, S.K., Lim, H., Paria, B.C., Dey, S.K. J. Mol. Endocrinol. (1999) [Pubmed]
  18. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency. Yue, L., Daikoku, T., Hou, X., Li, M., Wang, H., Nojima, H., Dey, S.K., Das, S.K. Endocrinology. (2005) [Pubmed]
  19. Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation. Daikoku, T., Song, H., Guo, Y., Riesewijk, A., Mosselman, S., Das, S.K., Dey, S.K. Mol. Endocrinol. (2004) [Pubmed]
  20. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Bagot, C.N., Kliman, H.J., Taylor, H.S. Dev. Dyn. (2001) [Pubmed]
  21. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Benson, G.V., Lim, H., Paria, B.C., Satokata, I., Dey, S.K., Maas, R.L. Development (1996) [Pubmed]
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