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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Dependovirus


Psychiatry related information on Dependovirus


High impact information on Dependovirus

  • Subretinal injection of recombinant adeno-associated virus (AAV) encoding a Prph2 transgene results in stable generation of outer segment structures and formation of new stacks of discs containing both perpherin-2 and rhodopsin, which in many cases are morphologically similar to normal outer segments [8].
  • Moreover, injection of adeno-associated viruses carrying micro-dystrophins into dystrophic muscles of immunocompetent mdx mice results in a striking reversal of histopathological features of this disease [9].
  • We report here that adeno-associated virus (AAV) selectively induces apoptosis in cells that lack active p53 [10].
  • We used a recombinant adeno-associated virus (rAAV) that expresses a single-chain insulin analogue (SIA), which possesses biologically active insulin activity without enzymatic conversion, under the control of hepatocyte-specific L-type pyruvate kinase (LPK) promoter, which regulates SIA expression in response to blood glucose levels [11].
  • Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2 [12].

Chemical compound and disease context of Dependovirus


Biological context of Dependovirus


Anatomical context of Dependovirus


Gene context of Dependovirus


Analytical, diagnostic and therapeutic context of Dependovirus

  • To test the feasibility of muscle-directed gene therapy to prevent type 1 diabetes, we developed recombinant adeno-associated virus (rAAV) vectors containing murine cDNAs for immunomodulatory cytokines IL-4 or IL-10 [33].
  • Newborn MPS VII mice received a single intravenous injection with 5.4 x 10(6) infectious units of recombinant adeno-associated virus encoding the human beta-glucuronidase (GUSB) cDNA [34].
  • In the first, recombinant adeno-associated virus was used to overexpress the human LEF1 gene in a human bronchial xenograft model of regenerative gland development in the adult airway [35].
  • Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection [36].
  • We examined cytoplasmic trafficking and nuclear translocation of adeno-associated virus type 2 (AAV) by using Alexa Fluor 488-conjugated wild-type AAV, A20 monoclonal antibody immunocytochemistry, and subcellular fractionation techniques followed by DNA hybridization [37].


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  13. AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Summerford, C., Bartlett, J.S., Samulski, R.J. Nat. Med. (1999) [Pubmed]
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  19. DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Russell, D.W., Alexander, I.E., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. Tsui, T.Y., Lau, C.K., Ma, J., Wu, X., Wang, Y.Q., Farkas, S., Xu, R., Schlitt, H.J., Fan, S.T. Hepatology (2005) [Pubmed]
  21. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor. Qiu, J., Pintel, D.J. J. Biol. Chem. (2004) [Pubmed]
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  27. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Barton-Davis, E.R., Shoturma, D.I., Musaro, A., Rosenthal, N., Sweeney, H.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Inhibition of S-phase progression by adeno-associated virus Rep78 protein is mediated by hypophosphorylated pRb. Saudan, P., Vlach, J., Beard, P. EMBO J. (2000) [Pubmed]
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  30. Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway. Zhang, L.N., Karp, P., Gerard, C.J., Pastor, E., Laux, D., Munson, K., Yan, Z., Liu, X., Godwin, S., Thomas, C.P., Zabner, J., Shi, H., Caldwell, C.W., Peluso, R., Carter, B., Engelhardt, J.F. Mol. Ther. (2004) [Pubmed]
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  32. Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Yoshioka, T., Okada, T., Maeda, Y., Ikeda, U., Shimpo, M., Nomoto, T., Takeuchi, K., Nonaka-Sarukawa, M., Ito, T., Takahashi, M., Matsushita, T., Mizukami, H., Hanazono, Y., Kume, A., Ookawara, S., Kawano, M., Ishibashi, S., Shimada, K., Ozawa, K. Gene Ther. (2004) [Pubmed]
  33. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Goudy, K., Song, S., Wasserfall, C., Zhang, Y.C., Kapturczak, M., Muir, A., Powers, M., Scott-Jorgensen, M., Campbell-Thompson, M., Crawford, J.M., Ellis, T.M., Flotte, T.R., Atkinson, M.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  34. Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease. Daly, T.M., Vogler, C., Levy, B., Haskins, M.E., Sands, M.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  35. Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Duan, D., Yue, Y., Zhou, W., Labed, B., Ritchie, T.C., Grosschedl, R., Engelhardt, J.F. Development (1999) [Pubmed]
  36. Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. Wobus, C.E., Hügle-Dörr, B., Girod, A., Petersen, G., Hallek, M., Kleinschmidt, J.A. J. Virol. (2000) [Pubmed]
  37. Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2. Xiao, W., Warrington, K.H., Hearing, P., Hughes, J., Muzyczka, N. J. Virol. (2002) [Pubmed]
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