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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Models, Genetic

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Disease relevance of Models, Genetic


Psychiatry related information on Models, Genetic


High impact information on Models, Genetic

  • Our study identifies a paradoxical protective role for Mmp8 in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility [11].
  • Mice lacking Cdc25b provide the first genetic model for studying the mechanisms regulating prophase arrest in vertebrates [12].
  • We propose a genetic model for the interaction of the Ah and hr loci, to account for the differential response to TCDD observed in the skin of HRS/J hr/hr and hr/+ mice [13].
  • Genetic models of junctional plasticity and genetic manipulations using the translation initiation factors eIF4E and poly(A)-binding protein showed an increased occurrence of subsynaptic translation aggregates [14].
  • Here, we show that a second vitamin, myo-inositol, is capable of significantly reducing the incidence of spinal NTDs in curly tail mice, a genetic model of folate-resistant NTDs [15].

Chemical compound and disease context of Models, Genetic


Biological context of Models, Genetic


Anatomical context of Models, Genetic


Associations of Models, Genetic with chemical compounds

  • Genetic model fitting was performed to estimate the magnitude and correlation of genetic and environmental contributions to lifetime nicotine and alcohol dependence [31].
  • Segregation of H and Se is compatible with the genetic model proposing that Se and H are closely linked structural genes, and the analysis of the present and previously published Bombay pedigrees strongly supports this model [32].
  • As juvenile hormone is an insect sesquiterpenoid related to retinoic acid, these results establish a new genetic model for studying organ looping and demonstrate an evolutionarily conserved role for terpenoids in this process [33].
  • Reversible impairment of glucose-induced insulin secretion in SHR/N-cp rats. Genetic model of type II diabetes [34].
  • These studies establish a means to evaluate mechanisms and consequences of integrin affinity modulation in a tractable model genetic system [35].

Gene context of Models, Genetic

  • The genetic and molecular characterization of Drosophila filamin provides the first genetic model system for the analysis of filamin function and regulation during development [36].
  • This study establishes the first genetic model for CDH and identifies a previously unsuspected role for Slit3 in regulating the development of the diaphragm [37].
  • Linkage to candidate genes COL9A1, COL9A2, and COL11A2 was tested and excluded for both genetic models in this family [38].
  • Thus, despite only modest changes in IGF and IGFBP concentrations, the Igfbp5-overexpressing mice displayed a phenotype more extreme than that observed for other Igfbp genetic models [39].
  • Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94% [40].

Analytical, diagnostic and therapeutic context of Models, Genetic


  1. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Satokata, I., Maas, R. Nat. Genet. (1994) [Pubmed]
  2. Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model. Malkinson, A.M., Nesbitt, M.N., Skamene, E. J. Natl. Cancer Inst. (1985) [Pubmed]
  3. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Holtzman, D.M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D.J., Daniels, S.E., Johnson, R.M., Chen, K., Sun, Y., Carlson, E., Alleva, E., Epstein, C.J., Mobley, W.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Kishimoto, I., Rossi, K., Garbers, D.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Schoonjans, K., Dubuquoy, L., Mebis, J., Fayard, E., Wendling, O., Haby, C., Geboes, K., Auwerx, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Alzheimer's disease. Chun, M.R., Mayeux, R. Curr. Opin. Neurol. (1994) [Pubmed]
  7. Pharmacogenetics of cocaine: a critical review. Morse, A.C., Erwin, V.G., Jones, B.C. Pharmacogenetics (1995) [Pubmed]
  8. Akt is altered in an animal model of Huntington's disease and in patients. Colin, E., Régulier, E., Perrin, V., Dürr, A., Brice, A., Aebischer, P., Déglon, N., Humbert, S., Saudou, F. Eur. J. Neurosci. (2005) [Pubmed]
  9. Serotonergic dorsal raphe neurons from obese zucker rats are hyperexcitable. Ohliger-Frerking, P., Horwitz, B.A., Horowitz, J.M. Neuroscience (2003) [Pubmed]
  10. The effect of spontaneous seizures on pentylenetetrazole and maximum electroshock induced seizures in the Mongolian gerbil. Lee, R.J., Lomax, P. Eur. J. Pharmacol. (1984) [Pubmed]
  11. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Balbín, M., Fueyo, A., Tester, A.M., Pendás, A.M., Pitiot, A.S., Astudillo, A., Overall, C.M., Shapiro, S.D., López-Otín, C. Nat. Genet. (2003) [Pubmed]
  12. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln, A.J., Wickramasinghe, D., Stein, P., Schultz, R.M., Palko, M.E., De Miguel, M.P., Tessarollo, L., Donovan, P.J. Nat. Genet. (2002) [Pubmed]
  13. Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: interaction of the ah and hr loci. Knutson, J.C., Poland, A. Cell (1982) [Pubmed]
  14. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P., Schuster, C.M. Nature (2000) [Pubmed]
  15. Inositol prevents folate-resistant neural tube defects in the mouse. Greene, N.D., Copp, A.J. Nat. Med. (1997) [Pubmed]
  16. Ca(2+)-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. Lucchesi, P.A., Bell, J.M., Willis, L.S., Byron, K.L., Corson, M.A., Berk, B.C. Circ. Res. (1996) [Pubmed]
  17. Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Koyama, M., Wada, R., Sakuraba, H., Mizukami, H., Yagihashi, S. Am. J. Pathol. (1998) [Pubmed]
  18. Reduced sensitivity of dihydroxyacetone on ATP-sensitive K+ channels of pancreatic beta cells in GK rats. Tsuura, Y., Ishida, H., Okamoto, Y., Kato, S., Horie, M., Ikeda, H., Seino, Y. Diabetologia (1994) [Pubmed]
  19. The presence of genetic hypertension stimulates early renal accumulation of fibronectin in experimental diabetes mellitus. Righetti, A.E., Boer-Lima, P.A., Lopes de Faria, J.B. Diabetologia (2001) [Pubmed]
  20. Dopamine D1 receptor gene polymorphism is associated with essential hypertension. Sato, M., Soma, M., Nakayama, T., Kanmatsuse, K. Hypertension (2000) [Pubmed]
  21. Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Dammai, V., Adryan, B., Lavenburg, K.R., Hsu, T. Genes Dev. (2003) [Pubmed]
  22. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. Groth, A., Lukas, J., Nigg, E.A., Silljé, H.H., Wernstedt, C., Bartek, J., Hansen, K. EMBO J. (2003) [Pubmed]
  23. Physiological and immunopathological consequences of active immunization of spontaneously hypertensive and normotensive rats against murine renin. Michel, J.B., Sayah, S., Guettier, C., Nussberger, J., Philippe, M., Gonzalez, M.F., Carelli, C., Galen, F.X., Menard, J., Corvol, P. Circulation (1990) [Pubmed]
  24. Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Roper, R.J., Baxter, L.L., Saran, N.G., Klinedinst, D.K., Beachy, P.A., Reeves, R.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  25. A combined segregation and linkage analysis of insulin-dependent diabetes mellitus. Rich, S.S., Green, A., Morton, N.E., Barbosa, J. Am. J. Hum. Genet. (1987) [Pubmed]
  26. SOX2 functions in adult neural stem cells. Episkopou, V. Trends Neurosci. (2005) [Pubmed]
  27. Transplantation of ventral mesencephalic anlagen to hosts with genetic nigrostriatal dopamine deficiency. Triarhou, L.C., Low, W.C., Ghetti, B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  28. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Williams, B.L., Schreiber, K.L., Zhang, W., Wange, R.L., Samelson, L.E., Leibson, P.J., Abraham, R.T. Mol. Cell. Biol. (1998) [Pubmed]
  29. Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. MacDonald, M.J., Efendić, S., Ostenson, C.G. Diabetes (1996) [Pubmed]
  30. Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons. Habener, J.F., Cwikel, B.J., Hermann, H., Hammer, R.E., Palmiter, R.D., Brinster, R.L. J. Biol. Chem. (1989) [Pubmed]
  31. Common genetic vulnerability for nicotine and alcohol dependence in men. True, W.R., Xian, H., Scherrer, J.F., Madden, P.A., Bucholz, K.K., Heath, A.C., Eisen, S.A., Lyons, M.J., Goldberg, J., Tsuang, M. Arch. Gen. Psychiatry (1999) [Pubmed]
  32. H-deficient blood groups ( Bombay) of Reunion Island. Gerard, G., Vitrac, D., Le Pendu, J., Muller, A., Oriol, R. Am. J. Hum. Genet. (1982) [Pubmed]
  33. The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila. Adám, G., Perrimon, N., Noselli, S. Development (2003) [Pubmed]
  34. Reversible impairment of glucose-induced insulin secretion in SHR/N-cp rats. Genetic model of type II diabetes. Voyles, N.R., Powell, A.M., Timmers, K.I., Wilkins, S.D., Bhathena, S.J., Hansen, C., Michaelis, O.E., Recant, L. Diabetes (1988) [Pubmed]
  35. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. Bunch, T.A., Helsten, T.L., Kendall, T.L., Shirahatti, N., Mahadevan, D., Shattil, S.J., Brower, D.L. J. Biol. Chem. (2006) [Pubmed]
  36. Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis. Li, M.G., Serr, M., Edwards, K., Ludmann, S., Yamamoto, D., Tilney, L.G., Field, C.M., Hays, T.S. J. Cell Biol. (1999) [Pubmed]
  37. A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Yuan, W., Rao, Y., Babiuk, R.P., Greer, J.J., Wu, J.Y., Ornitz, D.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  38. Genetic heterogeneity in multiple epiphyseal dysplasia. Deere, M., Blanton, S.H., Scott, C.I., Langer, L.O., Pauli, R.M., Hecht, J.T. Am. J. Hum. Genet. (1995) [Pubmed]
  39. Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice. Salih, D.A., Tripathi, G., Holding, C., Szestak, T.A., Gonzalez, M.I., Carter, E.J., Cobb, L.J., Eisemann, J.E., Pell, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  40. The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Tonin, P., Serova, O., Simard, J., Lenoir, G., Feunteun, J., Morgan, K., Lynch, H., Narod, S. Hum. Mol. Genet. (1994) [Pubmed]
  41. Dichloroacetate. Stacpoole, P.W., Greene, Y.J. Diabetes Care (1992) [Pubmed]
  42. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Holtzman, D.M., Li, Y., Chen, K., Gage, F.H., Epstein, C.J., Mobley, W.C. Neurology (1993) [Pubmed]
  43. Twin studies of Alzheimer disease: II. Some predictions under a genetic model. Breitner, J.C., Murphy, E.A. Am. J. Med. Genet. (1992) [Pubmed]
  44. Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats. Coenen, A.M., Drinkenburg, W.H., Inoue, M., van Luijtelaar, E.L. Epilepsy Res. (1992) [Pubmed]
  45. Differential effects mediated by GABAA receptors in thalamic nuclei in lh/lh model of absence seizures. Hosford, D.A., Wang, Y., Cao, Z. Epilepsy Res. (1997) [Pubmed]
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