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Gene Review

Itpr3  -  inositol 1,4,5-triphosphate receptor 3

Mus musculus

Synonyms: IP3 receptor isoform 3, IP3R 3, Inositol 1,4,5-trisphosphate receptor type 3, InsP3R3, Ip3r3, ...
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High impact information on Itpr3


Anatomical context of Itpr3

  • We demonstrated also that: 1) type 1 InsP3 receptors were localized at the nuclear membrane level while type 3 were absent from the nucleus; 2) calcium release from nuclear stores was mediated by type 1 rather than type 3 InsP3 receptor associated channels; 3) the anti-InsP3 R-1 mAB microinjected into the nucleus inhibited the GVB [4].

Analytical, diagnostic and therapeutic context of Itpr3


  1. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Khan, A.A., Soloski, M.J., Sharp, A.H., Schilling, G., Sabatini, D.M., Li, S.H., Ross, C.A., Snyder, S.H. Science (1996) [Pubmed]
  2. The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cells. Colosetti, P., Tunwell, R.E., Cruttwell, C., Arsanto, J.P., Mauger, J.P., Cassio, D. J. Cell. Sci. (2003) [Pubmed]
  3. Promoter structure and gene expression of the mouse inositol 1,4,5-trisphosphate receptor type 3 gene. Tamura, T., Hashimoto, M., Aruga, J., Konishi, Y., Nakagawa, M., Ohbayashi, T., Shimada, M., Mikoshiba, K. Gene (2001) [Pubmed]
  4. Nuclear calcium release by InsP3-receptor channels plays a role in meiosis reinitiation in the mouse oocyte. Pesty, A., Avazeri, N., Lefèvre, B. Cell Calcium (1998) [Pubmed]
  5. Differential expression of type 2 and type 3 inositol 1,4,5-trisphosphate receptor mRNAs in various mouse tissues: in situ hybridization study. Fujino, I., Yamada, N., Miyawaki, A., Hasegawa, M., Furuichi, T., Mikoshiba, K. Cell Tissue Res. (1995) [Pubmed]
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