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Gene Review

Itpr3  -  inositol 1,4,5-trisphosphate receptor, type 3

Rattus norvegicus

Synonyms: IP3 receptor isoform 3, IP3R 3, IP3R3, IP3R3X, Inositol 1,4,5-trisphosphate receptor type 3, ...
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Disease relevance of Itpr3

  • In the present study, we show that thimerosal potentiated IICR (IP3-induced Ca2+ release) and IP3-binding activity of IP3R1, expressed in triple IP3R-knockout R23-11 cells derived from DT40 chicken B lymphoma cells, but not of IP3R3 or [D1-225]-IP3R1, which lacks the N-terminal suppressor domain [1].

High impact information on Itpr3


Biological context of Itpr3


Anatomical context of Itpr3


Associations of Itpr3 with chemical compounds


Regulatory relationships of Itpr3

  • Furthermore, we showed by double-immunolabeling methods that P2Y1-expressing cells coexpressed both IP3R3 and SNAP-25 [8].

Other interactions of Itpr3

  • We conclude that Ca2+ release mediated by the type-3 InsP3 receptor mainly differs from that mediated by the type-1 InsP3 receptor by its lack of stimulation by sulfhydryl oxidation and its lower ATP and InsP3 sensitivity [4].
  • Three mammalian InsP3R isoforms--InsP3R type 1 (InsP3R1), InsP3R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals, but the functional differences between the three mammalian InsP3R isoforms are poorly understood [9].
  • Western blotting was also performed with antibodies directed against GLUT1, glial fibrillary acidic protein, adaptin, IP3R-3, integrins alphav and collagen IV as controls to determine whether the preparations were contaminated by other membranes [10].
  • CaM kinase II was found throughout the entire intracellular canalicular F-actin domain of parietal cells, whereas the type 3 InsP3 receptor was restricted to the neck region [11].


  1. Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction. Bultynck, G., Szlufcik, K., Kasri, N.N., Assefa, Z., Callewaert, G., Missiaen, L., Parys, J.B., De Smedt, H. Biochem. J. (2004) [Pubmed]
  2. An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes. Vazquez, G., Wedel, B.J., Bird, G.S., Joseph, S.K., Putney, J.W. EMBO J. (2002) [Pubmed]
  3. Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells. Blondel, O., Moody, M.M., Depaoli, A.M., Sharp, A.H., Ross, C.A., Swift, H., Bell, G.I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Functional properties of the type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells. Missiaen, L., Parys, J.B., Sienaert, I., Maes, K., Kunzelmann, K., Takahashi, M., Tanzawa, K., De Smedt, H. J. Biol. Chem. (1998) [Pubmed]
  5. Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. Blackshaw, S., Sawa, A., Sharp, A.H., Ross, C.A., Snyder, S.H., Khan, A.A. FASEB J. (2000) [Pubmed]
  6. Expression patterns of sarco/endoplasmic reticulum Ca(2+)-ATPase and inositol 1,4,5-trisphosphate receptor isoforms in vascular endothelial cells. Mountian, I., Manolopoulos, V.G., De Smedt, H., Parys, J.B., Missiaen, L., Wuytack, F. Cell Calcium (1999) [Pubmed]
  7. Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. Blondel, O., Takeda, J., Janssen, H., Seino, S., Bell, G.I. J. Biol. Chem. (1993) [Pubmed]
  8. Expression of P2Y1 receptors in rat taste buds. Kataoka, S., Toyono, T., Seta, Y., Ogura, T., Toyoshima, K. Histochem. Cell Biol. (2004) [Pubmed]
  9. Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Tu, H., Wang, Z., Nosyreva, E., De Smedt, H., Bezprozvanny, I. Biophys. J. (2005) [Pubmed]
  10. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Beaulieu, E., Demeule, M., Ghitescu, L., Béliveau, R. Biochem. J. (1997) [Pubmed]
  11. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. Matovcik, L.M., Maranto, A.R., Soroka, C.J., Gorelick, F.S., Smith, J., Goldenring, J.R. J. Histochem. Cytochem. (1996) [Pubmed]
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