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Lect2  -  leukocyte cell-derived chemotaxin 2

Mus musculus

Synonyms: ChM-II, Chondromodulin II, LECT-2, Leukocyte cell-derived chemotaxin-2, chondromodulin-II
 
 
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Disease relevance of Lect2

  • Manipulation of LECT2 might provide a rationale for novel therapeutic approaches to the treatment of inflammatory arthritides such as RA [1].
 

High impact information on Lect2

 

Biological context of Lect2

 

Anatomical context of Lect2

  • However, ChM-II does not inhibit vascularization but stimulates osteoclast differentiation [4].
 

Associations of Lect2 with chemical compounds

  • We previously determined the complete primary sequence of a heparin-binding growth-promoting factor, chondromodulin-II (ChM-II), which stimulated the growth of chondrocytes and osteoblasts in culture [3].
 

Analytical, diagnostic and therapeutic context of Lect2

  • Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein [3].

References

  1. Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. Okumura, A., Saito, T., Otani, I., Kojima, K., Yamada, Y., Ishida-Okawara, A., Nakazato, K., Asano, M., Kanayama, K., Iwakura, Y., Suzuki, K., Yamagoe, S. Arthritis Rheum. (2008) [Pubmed]
  2. The mouse Lect2 gene: cloning of cDNA and genomic DNA, structural characterization and chromosomal localization. Yamagoe, S., Watanabe, T., Mizuno, S., Suzuki, K. Gene (1998) [Pubmed]
  3. Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein. Shukunami, C., Kondo, J., Wakai, H., Takahashi, K., Inoue, H., Kamizono, A., Hiraki, Y. J. Biochem. (1999) [Pubmed]
  4. Roles of cartilage matrix proteins, chondromodulin-I and -II, in endochondral bone formation: a review. Suzuki, F. Connect. Tissue Res. (1996) [Pubmed]
 
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