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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Arthritis


High impact information on Arthritis


Chemical compound and disease context of Arthritis


Biological context of Arthritis


Anatomical context of Arthritis


Gene context of Arthritis

  • Synovial membrane needle biopsy was performed on 15 PA patients with knee involvement (8 had asymmetric oligoarthritis and 7 had symmetric polyarthritis) and on 15 RA controls [27].
  • Since OSM, IL-6, and sIL-6R levels have all been shown to be elevated in the rheumatoid joint, our findings suggest that these cytokines may be key mediators of cartilage collagen catabolism in the inflammatory arthritides [28].
  • Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study [18].
  • RESULTS: Plasma levels of IL-1Ra, sIL-1RI, and sIL-1RII were significantly higher in polyarthritis patients than in controls [29].
  • In this study, we show that immunization with the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI) induces severe peripheral symmetric polyarthritis in normal mice [30].

Analytical, diagnostic and therapeutic context of Arthritis


  1. Letter: Polyarthritis associated with clindamycin-induced colitis. Rollins, D.E. JAMA (1975) [Pubmed]
  2. Quinidine-induced lupus erythematosus. West, S.G., McMahon, M., Portanova, J.P. Ann. Intern. Med. (1984) [Pubmed]
  3. Suppression of acute and chronic inflammation by orally administered prostaglandins. Kunkel, S.L., Ogawa, H., Conran, P.B., Ward, P.A., Zurier, R.B. Arthritis Rheum. (1981) [Pubmed]
  4. Rheumatologic manifestations of human parvovirus B19 infection in adults. Initial two-year clinical experience. Naides, S.J., Scharosch, L.L., Foto, F., Howard, E.J. Arthritis Rheum. (1990) [Pubmed]
  5. Cytotoxic anti-T cell antibodies in children with juvenile rheumatoid arthritis. Barron, K.S., Lewis, D.E., Brewer, E.J., Marcus, D.M., Shearer, W.T. Arthritis Rheum. (1984) [Pubmed]
  6. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Matsumoto, I., Staub, A., Benoist, C., Mathis, D. Science (1999) [Pubmed]
  7. Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis. Song, X., Zeng, L., Jin, W., Thompson, J., Mizel, D.E., Lei, K., Billinghurst, R.C., Poole, A.R., Wahl, S.M. J. Exp. Med. (1999) [Pubmed]
  8. Interleukin 6 is required for the development of collagen-induced arthritis. Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., Ciliberto, G. J. Exp. Med. (1998) [Pubmed]
  9. Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. Wahl, S.M., Allen, J.B., Costa, G.L., Wong, H.L., Dasch, J.R. J. Exp. Med. (1993) [Pubmed]
  10. Edema-producing activity of group A streptococcal polysaccharide and its possible role in the pathogenesis of cell wall-induced polyarthritis. Chetty, C., Brown, R.R., Schwab, J.H. J. Exp. Med. (1983) [Pubmed]
  11. Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan. Chang, Y.H., Pearson, C.M., Chedid, L. J. Exp. Med. (1981) [Pubmed]
  12. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. Sakurai, H., Kohsaka, H., Liu, M.F., Higashiyama, H., Hirata, Y., Kanno, K., Saito, I., Miyasaka, N. J. Clin. Invest. (1995) [Pubmed]
  13. Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo. Leroux, J.Y., Guerassimov, A., Cartman, A., Delaunay, N., Webber, C., Rosenberg, L.C., Banerjee, S., Poole, A.R. J. Clin. Invest. (1996) [Pubmed]
  14. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. Palombella, V.J., Conner, E.M., Fuseler, J.W., Destree, A., Davis, J.M., Laroux, F.S., Wolf, R.E., Huang, J., Brand, S., Elliott, P.J., Lazarus, D., McCormack, T., Parent, L., Stein, R., Adams, J., Grisham, M.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  15. Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritis. Cañete, J.D., Pablos, J.L., Sanmartí, R., Mallofré, C., Marsal, S., Maymó, J., Gratacós, J., Mezquita, J., Mezquita, C., Cid, M.C. Arthritis Rheum. (2004) [Pubmed]
  16. Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant-induced polyarthritis. Straub, R.H., Wolff, C., Fassold, A., Hofbauer, R., Chover-Gonzalez, A., Richards, L.J., Jessop, D.S. Arthritis Rheum. (2008) [Pubmed]
  17. Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis. Arnaud, P., Galbraith, R.M., Faulk, W.P. J. Clin. Invest. (1977) [Pubmed]
  18. Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study. Thomson, W., Harrison, B., Ollier, B., Wiles, N., Payton, T., Barrett, J., Symmons, D., Silman, A. Arthritis Rheum. (1999) [Pubmed]
  19. Juvenile rheumatoid arthritis-like polyarthritis in chromosome 22q11.2 deletion syndrome (DiGeorge anomalad/velocardiofacial syndrome/conotruncal anomaly face syndrome). Sullivan, K.E., McDonald-McGinn, D.M., Driscoll, D.A., Zmijewski, C.M., Ellabban, A.S., Reed, L., Emanuel, B.S., Zackai, E.H., Athreya, B.H., Keenan, G. Arthritis Rheum. (1997) [Pubmed]
  20. Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele. Levesque, M.C., Ward, F.E., Jeffery, D.R., Weinberg, J.B. Arthritis Rheum. (1999) [Pubmed]
  21. Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies. Shi, S., Ciurli, C., Cartman, A., Pidoux, I., Poole, A.R., Zhang, Y. Arthritis Rheum. (2003) [Pubmed]
  22. Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides. Malone, D.G., Irani, A.M., Schwartz, L.B., Barrett, K.E., Metcalfe, D.D. Arthritis Rheum. (1986) [Pubmed]
  23. IgG and IgM rheumatoid factor synthesis in rheumatoid synovial membrane cell cultures. Wernick, R.M., Lipsky, P.E., Marban-Arcos, E., Maliakkal, J.J., Edelbaum, D., Ziff, M. Arthritis Rheum. (1985) [Pubmed]
  24. IFN-gamma inhibits inflammatory cell recruitment and the evolution of bacterial cell wall-induced arthritis. Wahl, S.M., Allen, J.B., Ohura, K., Chenoweth, D.E., Hand, A.R. J. Immunol. (1991) [Pubmed]
  25. Regional variation and differential response to therapy for knee synovitis adjacent to the cartilage-pannus junction and suprapatellar pouch in inflammatory arthritis: implications for pathogenesis and treatment. Rhodes, L.A., Tan, A.L., Tanner, S.F., Radjenovic, A., Hensor, E.M., Reece, R., O'Connor, P., Emery, P., McGonagle, D. Arthritis Rheum. (2004) [Pubmed]
  26. Cellular immunology in a historical perspective. Good, R.A. Immunol. Rev. (2002) [Pubmed]
  27. Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis. Veale, D., Yanni, G., Rogers, S., Barnes, L., Bresnihan, B., Fitzgerald, O. Arthritis Rheum. (1993) [Pubmed]
  28. Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown. Rowan, A.D., Koshy, P.J., Shingleton, W.D., Degnan, B.A., Heath, J.K., Vernallis, A.B., Spaull, J.R., Life, P.F., Hudson, K., Cawston, T.E. Arthritis Rheum. (2001) [Pubmed]
  29. Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: correlations with markers of inflammation and joint destruction. Jouvenne, P., Vannier, E., Dinarello, C.A., Miossec, P. Arthritis Rheum. (1998) [Pubmed]
  30. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. Schubert, D., Maier, B., Morawietz, L., Krenn, V., Kamradt, T. J. Immunol. (2004) [Pubmed]
  31. Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis. Gonzalez-Gay, M.A., Nabozny, G.H., Bull, M.J., Zanelli, E., Douhan, J., Griffiths, M.M., Glimcher, L.H., Luthra, H.S., David, C.S. J. Exp. Med. (1994) [Pubmed]
  32. Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: immunologic, histopathologic, and other studies. Chang, Y.H., Pearson, C.M., Abe, C. Arthritis Rheum. (1980) [Pubmed]
  33. Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Namjou, B., Nath, S.K., Kilpatrick, J., Kelly, J.A., Reid, J., James, J.A., Harley, J.B. Arthritis Rheum. (2002) [Pubmed]
  34. An eight year prospective study of outcome prediction by antiperinuclear factor and antikeratin antibodies at onset of rheumatoid arthritis. Genevay, S., Hayem, G., Verpillat, P., Meyer, O. Ann. Rheum. Dis. (2002) [Pubmed]
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