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DHX36  -  DEAH (Asp-Glu-Ala-His) box polypeptide 36

Homo sapiens

Synonyms: ATP-dependent RNA helicase DHX36, DDX36, DEAH box protein 36, G4-resolvase 1, G4R1, ...
 
 
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Disease relevance of DHX36

 

High impact information on DHX36

 

Biological context of DHX36

 

Anatomical context of DHX36

  • Northern blotting of DDX36 shows a single strong signal of 3.8 kb in the hybridization pattern in human testis but no or very weak signal in other tissues [3].
 

Analytical, diagnostic and therapeutic context of DHX36

  • The DHX36 gene product was identified by mass spectrometric sequencing of a tryptic digest from the protein band on SDS-PAGE associated with activity [1].

References

  1. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. Vaughn, J.P., Creacy, S.D., Routh, E.D., Joyner-Butt, C., Jenkins, G.S., Pauli, S., Nagamine, Y., Akman, S.A. J. Biol. Chem. (2005) [Pubmed]
  2. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis. Fu, J.J., Li, L.Y., Liu, S.F., Xing, X.W., Liu, G., Lu, G.X. Yi Chuan Xue Bao (2003) [Pubmed]
  3. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. Fu, J.J., Li, L.Y., Lu, G.X. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2002) [Pubmed]
 
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