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Gene Review:

Kcng3 - potassium channel, voltage gated modifier...

Rattus norvegicus

Synonyms: Kv10.1, Kv6.3, Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv10.1, Voltage-gated potassium channel subunit Kv6.3

Vega-Saenz de Miera, E.C., Sano, Y. et al.

Sano, Mochizuki, Miyake, Kitada, Inamura, Yokoi, Nozawa, Matsushime, Furuichi,

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High impact information on Kcng3

The gene that encodes for Kv10.1 mRNAs maps to chromosome 2p22.1 in human, 6q12 in rat and 17E4 in mouse, locations consistent with the known systeny for human, rat and mouse chromosomes [1].
In situ hybridization in rat brain shows that Kv10.1 mRNAs are expressed in cortex, olfactory cortical structures, basal ganglia/striatal structures, hippocampus and in many nuclei of the amygdala complex [1].

Analytical, diagnostic and therapeutic context of Kcng3

Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain [2].
Immunoprecipitation studies indicated that Kv6.3 bound with Kv2.1 in co-transfected cells [2].
Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1 [2].

References

Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera, E.C. Brain Res. Mol. Brain Res. (2004) [Pubmed]
Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. Sano, Y., Mochizuki, S., Miyake, A., Kitada, C., Inamura, K., Yokoi, H., Nozawa, K., Matsushime, H., Furuichi, K. FEBS Lett. (2002) [Pubmed]

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