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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tm4sf1  -  transmembrane 4 superfamily member 1

Mus musculus

Synonyms: 12A8 target antigen, L6, L6 antigen, M3s1, Membrane component chromosome 3 surface marker 1 homolog, ...
 
 
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Disease relevance of Tm4sf1

  • The murine monoclonal antibody (mAb) L6 recognizes an integral membrane glycoprotein that is highly expressed on lung, breast, colon, and ovarian carcinomas and is referred to as the L6 antigen [1].
  • Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas [2].
  • The chimeric antibody, but not the mouse L6 antibody, is effective against a melanoma line expressing small amounts of the L6 antigen [3].
  • A panel of 13 renal cell carcinoma cell lines was evaluated for the expression of antigens recognized by the L6 and L49 monoclonal antibodies [4].
  • The L6 and L49 antibodies were chemically conjugated to Enterobacter cloacae beta-lactamase (bL), and their abilities to effect site-selective anticancer prodrug activation on two of the renal cell carcinoma cell lines (SN12P and 1934J) were evaluated in vitro and in vivo [4].
 

High impact information on Tm4sf1

  • Defining these specificities enabled us to select particular anti-ids for assays to monitor the pharmacokinetics of either murine or chimeric L6 antibodies in the circulation of human patients [5].
  • All of the cell lines were strongly positive for the L6 antigen, and 9/13 bound 96.5, which, like the L49 monoclonal antibody, recognizes the p97 melanotransferrin antigen [4].
  • Here we describe the preparation of the mAb 12A8, which was raised against murine thymic epithelial cells, the tissue distribution of the murine antigen recognized by 12A8, the cloning of a cDNA encoding the 12A8 target antigen, and the demonstration that this antigen is M-L6 [6].
 

Analytical, diagnostic and therapeutic context of Tm4sf1

  • Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens [6].
  • Sequence analysis showed that this gene is a member of the transmembrane 4 superfamily (TM4SF) and encodes the Syrian hamster counterpart of the human and the murine L6 antigens [7].

References

  1. Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. Marken, J.S., Bajorath, J., Edwards, C.P., Farr, A.G., Schieven, G.L., Hellström, I., Hellström, K.E., Aruffo, A. J. Biol. Chem. (1994) [Pubmed]
  2. Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas. Hellström, I., Beaumier, P.L., Hellström, K.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Chimeric mouse-human IgG1 antibody that can mediate lysis of cancer cells. Liu, A.Y., Robinson, R.R., Hellström, K.E., Murray, E.D., Chang, C.P., Hellström, I. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Therapeutic effects of monoclonal antibody-beta-lactamase conjugates in combination with a nitrogen mustard anticancer prodrug in models of human renal cell carcinoma. Svensson, H.P., Frank, I.S., Berry, K.K., Senter, P.D. J. Med. Chem. (1998) [Pubmed]
  5. Epitope mapping and use of anti-idiotypic antibodies to the L6 monoclonal anticarcinoma antibody. Hellström, K.E., Yelton, D.E., Fell, H.P., Beaton, D., Gayle, M., MacLean, M., Kahn, M., Hellström, I. Cancer Res. (1990) [Pubmed]
  6. Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens. Edwards, C.P., Farr, A.G., Marken, J.S., Nelson, A., Bajorath, J., Hellström, K.E., Hellström, I., Aruffo, A. Biochemistry (1995) [Pubmed]
  7. The cDNA cloning of the hamster homologue of the human L6 gene. Maruyama, M., Kozuka-Hata, K., Sakaguchi-Sanai, A., Shioda, S., Yamaguchi, N., Maruyama, K. Gene (1996) [Pubmed]
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