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Gene Review

Khsrp  -  KH-type splicing regulatory protein

Rattus norvegicus

Synonyms: FUSE-binding protein 2, Far upstream element-binding protein 2, Fubp2, KH type-splicing regulatory protein, KSRP, ...
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High impact information on Khsrp

  • In conclusion, AU-rich sequences of the 3'-UTR of collagenase 3 and vinculin and FUSE-binding protein 2 regulate collagenase mRNA stability in osteoblasts [1].
  • The zipcode-binding protein, KSRP, and hnRNP A2 were selected for further study and were shown by confocal immunofluorescence microscopy to have similar distributions in the central nervous system, but they were found in largely separate locations in cell nuclei [2].
  • In rat brain neurones and cultured neurones derived from superior cervical ganglia, MARTA1 is primarily intranuclear, but is also present in the somatodendritic cytoplasm [3].
  • Using this experimental system, two 90-kDa and 65-kDa MAP2-RNA trans-acting proteins, MARTA1 and MARTA2, were identified in rat-brain extracts [4].
  • Moreover, MARTA1 and MARTA2 do not bind significantly to other dendritically localized transcripts encoding vasopressin and arg3.1, nor to a dendritic trafficking element from the mRNA encoding the alpha-subunit of the Ca(2+)/calmodulin-dependent protein kinase II [4].


  1. AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts. Rydziel, S., Delany, A.M., Canalis, E. J. Biol. Chem. (2004) [Pubmed]
  2. RNA trafficking and stabilization elements associate with multiple brain proteins. Snee, M., Kidd, G.J., Munro, T.P., Smith, R. J. Cell. Sci. (2002) [Pubmed]
  3. Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs. Rehbein, M., Wege, K., Buck, F., Schweizer, M., Richter, D., Kindler, S. J. Neurochem. (2002) [Pubmed]
  4. Two trans-acting rat-brain proteins, MARTA1 and MARTA2, interact specifically with the dendritic targeting element in MAP2 mRNAs. Rehbein, M., Kindler, S., Horke, S., Richter, D. Brain Res. Mol. Brain Res. (2000) [Pubmed]
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