Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

rbp5 - retinol binding protein 1a, cellular

Danio rerio

Synonyms: SO:0000704, cb465, rbp1, rbp1a, wu:fb75e07, ...

Liu, R.Z. et al., Liu, R.Z. et al.

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High impact information on rbp1a

Comparative analysis suggests that the duplicate genes of rbp1 and rbp2 in the zebrafish genome may have arisen by chromosomal or whole-genome duplication [1].
RT-PCR detected mRNA transcripts in the adult intestine, liver, brain, ovary and testis for rbp1 gene and in the intestine and liver for rbp2 gene [2].
Whole mount in situ hybridization of zebrafish embryos revealed rbp1 mRNA expression in the developing zebrafish central nervous system at specific sites that are known to have abundant retinoic acid distribution and significant retinoic acid action [2].

Biological context of rbp1a

Two transcription start sites were identified in the rbp1 promoter and a single transcription start site was identified for rbp2 [2].
The zebrafish CRBPI gene (rbp1) and CRBPII gene (rbp2) both consist of four exons separated by three introns, identical to all other iLBP genes in vertebrates [2].

Analytical, diagnostic and therapeutic context of rbp1a

Radiation hybrid mapping assigned the zebrafish rbp1 gene to linkage group 16 and conserved syntenic genes were found by comparative analysis of mammalian orthologous rbp1 genes [2].

References

The cellular retinol-binding protein genes are duplicated and differentially transcribed in the developing and adult zebrafish (Danio rerio). Liu, R.Z., Sun, Q., Thisse, C., Thisse, B., Wright, J.M., Denovan-Wright, E.M. Mol. Biol. Evol. (2005) [Pubmed]
Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio). Liu, R.Z., Denovan-Wright, E.M., Degrave, A., Thisse, C., Thisse, B., Wright, J.M. Eur. J. Biochem. (2004) [Pubmed]

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