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Gene Review: 

fabp10a  -  fatty acid binding protein 10a, liver basic

Danio rerio

Synonyms: Fatty acid-binding protein 10-A, liver basic, Fatty acid-binding protein, liver, L-BABP, L-FABP, Lb-FABP, ...
 
 
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Disease relevance of fabp10

  • Liver fatty acid binding protein (L-FABP) is a small protein that is thought to play an important role in the intracellular binding and trafficking of long chain fatty acids in the liver [1].
 

High impact information on fabp10

  • Expression of the gene encoding the zebrafish liver fatty acid binding protein is regulated by a 435-bp distal region (-1944 to -1510) of the L-FABP promoter [1].
  • The importance of the HNF-1alpha consensus binding site in the A element and the HNF-3beta consensus binding site in the B element within the 435-bp distal region of the L-FABP promoter region suggests that combinatorial interactions between multiple regulatory factors are responsible for the gene expression of L-FABP in the liver [1].
  • Mammalian liver fatty acid binding protein (L-FABP) is a small cytosolic protein in various tissues including liver, small intestine and kidney and is thought to play a crucial role in intracellular fatty acid trafficking and metabolism [2].
  • The differential and complementary expression patterns of the zebrafish fabp1a, fapb1b and fabp10 genes imply a hierarchical subfunctionalization that may account for the retention of both the duplicated fabp1a and fabp1b genes, and the fabp10 gene in the zebrafish genome [3].
 

Biological context of fabp10

  • Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome [3].

References

  1. 435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish. Her, G.M., Yeh, Y.H., Wu, J.L. Dev. Dyn. (2003) [Pubmed]
  2. In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). Her, G.M., Chiang, C.C., Chen, W.Y., Wu, J.L. FEBS Lett. (2003) [Pubmed]
  3. Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome. Sharma, M.K., Liu, R.Z., Thisse, C., Thisse, B., Denovan-Wright, E.M., Wright, J.M. FEBS J. (2006) [Pubmed]
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