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Gene Review

Dnm3  -  dynamin 3

Rattus norvegicus

Synonyms: Dyn3, Dynamin, testicular, Dynamin-3, T-dynamin
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High impact information on Dnm3

  • Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer [1].
  • Dyn1 concentrates within the presynaptic compartment, while Dyn3 localizes to dendritic spine tips [1].
  • Finally, although dominant-negative Dyn3 did not seem to inhibit receptor endocytosis, overexpression of a specific Dyn3 spliced variant in mature neurons caused a marked remodeling of dendritic spines [1].
  • Within the postsynaptic density (PSD), we found Dyn3, but not Dyn1, to be part of a biochemically isolated complex comprised of Homer and metabotropic glutamate receptors [1].
  • This effect is dependent upon Dyn3 GTPase activity and a direct interaction with the F-actin-binding protein cortactin [2].

Biological context of Dnm3


Anatomical context of Dnm3

  • Here, we demonstrate that a specific Dyn3 variant (Dyn3baa) promotes the formation of immature dendritic filopodia in cultured neurons [2].

Other interactions of Dnm3

  • Together, these findings provide the first evidence that an enhanced interaction between a specific Dyn3 splice variant and cortactin modulate actin-membrane dynamics in developing neurons to regulate the morphogenesis of dendritic spines [2].
  • Dynamin-1 and -2 were expressed at similar high levels, whereas dynamin-3 was of low abundance [3].

Analytical, diagnostic and therapeutic context of Dnm3


  1. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Gray, N.W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B.J., Hémar, A., McNiven, M.A. Curr. Biol. (2003) [Pubmed]
  2. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. Gray, N.W., Kruchten, A.E., Chen, J., McNiven, M.A. J. Cell. Sci. (2005) [Pubmed]
  3. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner, R., Gratzl, M., Prinz, C. J. Cell. Sci. (2004) [Pubmed]
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