High impact information on Dnm3

• Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer [1].
• Dyn1 concentrates within the presynaptic compartment, while Dyn3 localizes to dendritic spine tips [1].
• Finally, although dominant-negative Dyn3 did not seem to inhibit receptor endocytosis, overexpression of a specific Dyn3 spliced variant in mature neurons caused a marked remodeling of dendritic spines [1].
• Within the postsynaptic density (PSD), we found Dyn3, but not Dyn1, to be part of a biochemically isolated complex comprised of Homer and metabotropic glutamate receptors [1].
• This effect is dependent upon Dyn3 GTPase activity and a direct interaction with the F-actin-binding protein cortactin [2].

Biological context of Dnm3

• A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines [2].

Anatomical context of Dnm3

• Here, we demonstrate that a specific Dyn3 variant (Dyn3baa) promotes the formation of immature dendritic filopodia in cultured neurons [2].

Other interactions of Dnm3

• Together, these findings provide the first evidence that an enhanced interaction between a specific Dyn3 splice variant and cortactin modulate actin-membrane dynamics in developing neurons to regulate the morphogenesis of dendritic spines [2].
• Dynamin-1 and -2 were expressed at similar high levels, whereas dynamin-3 was of low abundance [3].

Analytical, diagnostic and therapeutic context of Dnm3

• Immunofluorescence microscopy located dynamin-1 and -2 to the cytoplasm and cell surface, whereas dynamin-3 was distributed differently in the perinuclear area [3].

References