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Gene Review

Cttn  -  cortactin

Rattus norvegicus

Synonyms: Src substrate cortactin
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Psychiatry related information on Cttn

  • REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity [1].

High impact information on Cttn


Biological context of Cttn


Anatomical context of Cttn

  • Taken together, these results suggest a role for PAK-phosphorylation of cortactin in the regulation of the dynamics of branched actin filaments in dynamic cytoskeletal organelles [3].
  • We have shown previously that Src-phosphorylation of cortactin is not required for its translocation to phorbol-ester induced podosomes in A7r5 aortic smooth muscle cells, but may be important for stability and turnover of podosomes [3].
  • Furthermore, selective disruption of the cortactin-Dyn2 interaction significantly reduces the levels of Dyn2 at the Golgi and blocks the transit of nascent proteins from the trans-Golgi network, resulting in swollen and distended cisternae [2].
  • Thus, cortactin provides a direct link between the dynamic actin cytoskeleton and the membrane pinchase dynamin that supports vesicle formation during receptor-mediated endocytosis [6].
  • These findings suggest that cortactin is an important component of the receptor-mediated endocytic machinery, where, together with actin and dynamin, it regulates the scission of clathrin pits from the plasma membrane [6].

Associations of Cttn with chemical compounds

  • Thus cortactin, and phosphorylation of its tyrosine residues, are important for N-cadherin-mediated intercellular adhesion strength [4].
  • The Src kinase inhibitor SU-6656 significantly inhibited formation of podosomes induced by phorbol ester and phosphorylation of cortactin, whereas PKCalpha inhibitor did not affect podosome formation in c-Src-transfected cells [7].
  • In addition to its PDZ domain, Shank contains a proline-rich region that binds to cortactin and a SAM domain that mediates multimerization [8].
  • Pretreatment of EC with C3 transferase, a specific inhibitor of Rho proteins, significantly inhibited the transmonolayer migration of T lymphocytes, endothelial Rho-GTP loading, and endothelial actin reorganization, without affecting either lymphocyte adhesion to EC or cortactin phosphorylation [9].
  • The PC group had more total and tyrosine-phosphorylated cortactin protein expression than the RD and CC groups [1].

Physical interactions of Cttn

  • This effect is dependent upon Dyn3 GTPase activity and a direct interaction with the F-actin-binding protein cortactin [5].

Other interactions of Cttn


Analytical, diagnostic and therapeutic context of Cttn


  1. REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity. Davis, C.J., Meighan, P.C., Taishi, P., Krueger, J.M., Harding, J.W., Wright, J.W. Neurosci. Lett. (2006) [Pubmed]
  2. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Cao, H., Weller, S., Orth, J.D., Chen, J., Huang, B., Chen, J.L., Stamnes, M., McNiven, M.A. Nat. Cell Biol. (2005) [Pubmed]
  3. Phosphorylation of cortactin by p21-activated kinase. Webb, B.A., Zhou, S., Eves, R., Shen, L., Jia, L., Mak, A.S. Arch. Biochem. Biophys. (2006) [Pubmed]
  4. Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts. El Sayegh, T.Y., Arora, P.D., Laschinger, C.A., Lee, W., Morrison, C., Overall, C.M., Kapus, A., McCulloch, C.A. J. Cell. Sci. (2004) [Pubmed]
  5. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. Gray, N.W., Kruchten, A.E., Chen, J., McNiven, M.A. J. Cell. Sci. (2005) [Pubmed]
  6. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Cao, H., Orth, J.D., Chen, J., Weller, S.G., Heuser, J.E., McNiven, M.A. Mol. Cell. Biol. (2003) [Pubmed]
  7. Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. Zhou, S., Webb, B.A., Eves, R., Mak, A.S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  8. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Naisbitt, S., Kim, E., Tu, J.C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R.J., Worley, P.F., Sheng, M. Neuron (1999) [Pubmed]
  9. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. Adamson, P., Etienne, S., Couraud, P.O., Calder, V., Greenwood, J. J. Immunol. (1999) [Pubmed]
  10. Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. Boeckers, T.M., Kreutz, M.R., Winter, C., Zuschratter, W., Smalla, K.H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C.C., Gundelfinger, E.D. J. Neurosci. (1999) [Pubmed]
  11. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Rauvala, H., Huttunen, H.J., Fages, C., Kaksonen, M., Kinnunen, T., Imai, S., Raulo, E., Kilpeläinen, I. Matrix Biol. (2000) [Pubmed]
  12. Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Touyz, R.M., Wu, X.H., He, G., Salomon, S., Schiffrin, E.L. Hypertension (2002) [Pubmed]
  13. ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. Etienne-Manneville, S., Manneville, J.B., Adamson, P., Wilbourn, B., Greenwood, J., Couraud, P.O. J. Immunol. (2000) [Pubmed]
  14. Actin-dependent anterograde movement of growth-cone-like structures along growing hippocampal axons: a novel form of axonal transport? Ruthel, G., Banker, G. Cell Motil. Cytoskeleton (1998) [Pubmed]
  15. Actin filament organization of foot processes in rat podocytes. Ichimura, K., Kurihara, H., Sakai, T. J. Histochem. Cytochem. (2003) [Pubmed]
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