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Gene Review

ubc-25  -  Protein UBC-25

Caenorhabditis elegans

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High impact information on ubc-25

  • Caenorhabditis elegans gene ubc-25 encodes a novel type of an E2 ubiquitin transferase domain (UBCc) protein, which is highly conserved in multicellular animals, but which is not present in the genomes of fungi or plants [1].
  • These experiments showed that ubc-25 expression starts during embryogenesis and that it is restricted to neurons and muscle cells in all later stages of development as well as in adult animals [1].
  • We therefore propose that ubc-25 in C. elegans is required for the maintenance (homeostasis) of neuromuscular functions by contributing to a tissue specific protein modification pathway, and we speculate that the adult onset phenotype results from the accumulation of target proteins which fail to be degraded [1].
  • RNA interference with ubc-25 caused late-onset paralysis of most muscular functions such as locomotion, egg laying, and defecation [1].


  1. The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans. Schulze, E., Altmann, M.E., Adham, I.M., Schulze, B., Fröde, S., Engel, W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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