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Gene Review

sur-2  -  Protein SUR-2

Caenorhabditis elegans

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High impact information on sur-2


Biological context of sur-2

  • Genetic epistasis analyses suggest that sur-2 is required late in the vulval signaling pathway, downstream of let-60 Ras, and is likely to act downstream of the Raf/MAP Kinase cascade [1].


  1. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Singh, N., Han, M. Genes Dev. (1995) [Pubmed]
  2. Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates. Nilsson, L., Li, X., Tiensuu, T., Auty, R., Greenwald, I., Tuck, S. Development (1998) [Pubmed]
  3. sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans. Gupta, B.P., Liu, J., Hwang, B.J., Moghal, N., Sternberg, P.W. Genetics (2006) [Pubmed]
  4. Multiple genes affect sensitivity of Caenorhabditis elegans to the bacterial pathogen Microbacterium nematophilum. Gravato-Nobre, M.J., Nicholas, H.R., Nijland, R., O'Rourke, D., Whittington, D.E., Yook, K.J., Hodgkin, J. Genetics (2005) [Pubmed]
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