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Gene Review

srf-3  -  Protein SRF-3

Caenorhabditis elegans

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Disease relevance of srf-3


High impact information on srf-3

  • The antigen-defective phenotype of srf-3 was epistatic to the heterochronic mutant phenotype of srf-(yj43) in immunofluorescence tests of the srf-3 srf-(yj43) double mutant, suggesting that srf-(yj43) causes incorrect regulation of a pathway of antigen formation that requires wild-type srf-3 activity [3].
  • We cloned srf-3 and found that it encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi apparatus membrane. srf-3 is exclusively expressed in secretory cells, consistent with its proposed function in cuticle/surface modification [1].
  • These mutants, srf-2, srf-3, srf-5 and the dauer pathway gene daf-1, also exhibit altered binding of lectins to the nematode surface [4].


  1. Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence. Höflich, J., Berninsone, P., Göbel, C., Gravato-Nobre, M.J., Libby, B.J., Darby, C., Politz, S.M., Hodgkin, J., Hirschberg, C.B., Baumeister, R. J. Biol. Chem. (2004) [Pubmed]
  2. srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates. Cipollo, J.F., Awad, A.M., Costello, C.E., Hirschberg, C.B. J. Biol. Chem. (2004) [Pubmed]
  3. Altered expression of an L1-specific, O-linked cuticle surface glycoprotein in mutants of the nematode Caenorhabditis elegans. Hemmer, R.M., Donkin, S.G., Chin, K.J., Grenache, D.G., Bhatt, H., Politz, S.M. J. Cell Biol. (1991) [Pubmed]
  4. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Joshua, G.W., Karlyshev, A.V., Smith, M.P., Isherwood, K.E., Titball, R.W., Wren, B.W. Microbiology (Reading, Engl.) (2003) [Pubmed]
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