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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Epistasis, Genetic

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Disease relevance of Epistasis, Genetic

  • Genetic epistasis analysis indicates that OSR-1 regulates survival under osmotic stress via CaMKII and a conserved p38 MAP kinase signaling cascade and regulates osmotic avoidance and resistance to acute dehydration likely by distinct mechanisms [1].

High impact information on Epistasis, Genetic


Biological context of Epistasis, Genetic


Associations of Epistasis, Genetic with chemical compounds


Gene context of Epistasis, Genetic

  • Genetic epistasis experiments indicate that wg signaling operates by inactivating the zw3 repression of en autoactivation [13].
  • By genetic epistasis, we demonstrate that PGRP-LC acts upstream of the imd gene [14].
  • Genetic epistasis experiments indicate that lin-25 is required in the inductive signaling pathway downstream of let-60 Ras and the Raf/MAP kinase cascade [15].
  • These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression [16].
  • Although genetic epistasis experiments place IFT proteins downstream of the Hh receptor and upstream of the Gli transcription factors, the mechanism by which IFT regulates Gli function is unknown [17].


  1. Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Solomon, A., Bandhakavi, S., Jabbar, S., Shah, R., Beitel, G.J., Morimoto, R.I. Genetics (2004) [Pubmed]
  2. The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Sagasti, A., Hisamoto, N., Hyodo, J., Tanaka-Hino, M., Matsumoto, K., Bargmann, C.I. Cell (2001) [Pubmed]
  3. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Potter, C.J., Huang, H., Xu, T. Cell (2001) [Pubmed]
  4. RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis. Hirayama, T., Kieber, J.J., Hirayama, N., Kogan, M., Guzman, P., Nourizadeh, S., Alonso, J.M., Dailey, W.P., Dancis, A., Ecker, J.R. Cell (1999) [Pubmed]
  5. Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Grieder, N.C., Nellen, D., Burke, R., Basler, K., Affolter, M. Cell (1995) [Pubmed]
  6. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Sundaram, M., Han, M. Cell (1995) [Pubmed]
  7. Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms. Baratta, R., Di Paola, R., Spampinato, D., Fini, G., Marucci, A., Coco, A., Vigneri, R., Frittitta, L., Trischitta, V. J. Mol. Med. (2003) [Pubmed]
  8. Genetic resistance to Friend leukemia virus in mice: masking of Fv-2 phenotype by an epistatic gene, Fv-4. Odaka, T., Ikeda, H. Jpn. J. Exp. Med. (1977) [Pubmed]
  9. Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia. Abdelilah-Seyfried, S., Cox, D.N., Jan, Y.N. Development (2003) [Pubmed]
  10. Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. Bastiani, C.A., Gharib, S., Simon, M.I., Sternberg, P.W. Genetics (2003) [Pubmed]
  11. Schizosaccharomyces pombe replication and repair proteins: proliferating cell nuclear antigen (PCNA). Arroyo, M.P., Wang, T.S. Methods (1999) [Pubmed]
  12. Genetic determinants of nonmodulating hypertension. Kosachunhanun, N., Hunt, S.C., Hopkins, P.N., Williams, R.R., Jeunemaitre, X., Corvol, P., Ferri, C., Mortensen, R.M., Hollenberg, N.K., Williams, G.H. Hypertension (2003) [Pubmed]
  13. wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Siegfried, E., Chou, T.B., Perrimon, N. Cell (1992) [Pubmed]
  14. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Gottar, M., Gobert, V., Michel, T., Belvin, M., Duyk, G., Hoffmann, J.A., Ferrandon, D., Royet, J. Nature (2002) [Pubmed]
  15. lin-25, a gene required for vulval induction in Caenorhabditis elegans. Tuck, S., Greenwald, I. Genes Dev. (1995) [Pubmed]
  16. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Menon, K.P., Sanyal, S., Habara, Y., Sanchez, R., Wharton, R.P., Ramaswami, M., Zinn, K. Neuron (2004) [Pubmed]
  17. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Liu, A., Wang, B., Niswander, L.A. Development (2005) [Pubmed]
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