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Gene Review

Mmp3  -  matrix metallopeptidase 3

Mus musculus

Synonyms: EMS-2, MMP-3, Matrix metalloproteinase-3, SL-1, SLN-1, ...
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Disease relevance of Mmp3


High impact information on Mmp3


Chemical compound and disease context of Mmp3


Biological context of Mmp3


Anatomical context of Mmp3


Associations of Mmp3 with chemical compounds


Physical interactions of Mmp3


Enzymatic interactions of Mmp3

  • It was concluded that MMP-3 cleaves HB-EGF at a specific site in the JM domain and that this enzyme might regulate the conversion of HB-EGF from being a juxtacrine to a paracrine/autocrine growth factor [24].
  • In vitro cleavage experiments revealed that MMP3 directly cleaves agrin [25].

Co-localisations of Mmp3


Regulatory relationships of Mmp3


Other interactions of Mmp3

  • Unlike stromelysin-1-deficient mice, gelatinase B-deficient mice exhibited a CHS response comparable to wild-type controls at 1 day postchallenge, but the response persisted beyond 7 days in contrast to the complete resolution observed in wild-type mice by 7 days [1].
  • Lethal infection induced increased levels of MMP-3 and MMP-12 mRNAs as well as that of tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) compared to sublethal infection [28].
  • In mouse osteoblastic cells, the expression ofMMP-2, MMP-3, and MMP-13 mRNAs could be detected, and they were markedly enhanced by IL-1alpha on days 2 and 5 [29].
  • Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice [16].
  • Northern blot analyses showed the transcripts for MMP-2, MMP-3, RNA on these days [30].

Analytical, diagnostic and therapeutic context of Mmp3


  1. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Wang, M., Qin, X., Mudgett, J.S., Ferguson, T.A., Senior, R.M., Welgus, H.G. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. Li, C.K., Pender, S.L., Pickard, K.M., Chance, V., Holloway, J.A., Huett, A., Gonçalves, N.S., Mudgett, J.S., Dougan, G., Frankel, G., MacDonald, T.T. J. Immunol. (2004) [Pubmed]
  3. Role of stromelysin 1 and gelatinase B in experimental acute lung injury. Warner, R.L., Beltran, L., Younkin, E.M., Lewis, C.S., Weiss, S.J., Varani, J., Johnson, K.J. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  4. Collagenase is expressed by rabbit VX2 tumour cells in syngeneic and xenogeneic hosts. Gavrilovic, J., Hembry, R.M., Reynolds, J.J., Murphy, G. Matrix (1989) [Pubmed]
  5. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G.D., Cleutjens, J.P., Shipley, M., Angellilo, A., Levi, M., Nübe, O., Baker, A., Keshet, E., Lupu, F., Herbert, J.M., Smits, J.F., Shapiro, S.D., Baes, M., Borgers, M., Collen, D., Daemen, M.J., Carmeliet, P. Nat. Med. (1999) [Pubmed]
  6. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Boudreau, N., Sympson, C.J., Werb, Z., Bissell, M.J. Science (1995) [Pubmed]
  7. Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways. Kerr, L.D., Holt, J.T., Matrisian, L.M. Science (1988) [Pubmed]
  8. The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Mayer, C., Bierhoff, H., Grummt, I. Genes Dev. (2005) [Pubmed]
  9. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Coussens, L.M., Raymond, W.W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G.H., Hanahan, D. Genes Dev. (1999) [Pubmed]
  10. Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. Fang, K.C., Raymond, W.W., Lazarus, S.C., Caughey, G.H. J. Clin. Invest. (1996) [Pubmed]
  11. Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice. Tamarat, R., Silvestre, J.S., Huijberts, M., Benessiano, J., Ebrahimian, T.G., Duriez, M., Wautier, M.P., Wautier, J.L., Lévy, B.I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  12. Molecular characterization of a novel transcription factor that controls stromelysin expression. Sanz, L., Moscat, J., Diaz-Meco, M.T. Mol. Cell. Biol. (1995) [Pubmed]
  13. Stromelysin-1 regulates adipogenesis during mammary gland involution. Alexander, C.M., Selvarajan, S., Mudgett, J., Werb, Z. J. Cell Biol. (2001) [Pubmed]
  14. Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Johnson, J.L., George, S.J., Newby, A.C., Jackson, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro. Breckon, J.J., Papaioannou, S., Kon, L.W., Tumber, A., Hembry, R.M., Murphy, G., Reynolds, J.J., Meikle, M.C. J. Bone Miner. Res. (1999) [Pubmed]
  16. Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice. Rudolph-Owen, L.A., Hulboy, D.L., Wilson, C.L., Mudgett, J., Matrisian, L.M. Endocrinology (1997) [Pubmed]
  17. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Han, Z., Boyle, D.L., Manning, A.M., Firestein, G.S. Autoimmunity (1998) [Pubmed]
  18. Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes. Witek-Zawada, B., Koj, A. J. Physiol. Pharmacol. (2003) [Pubmed]
  19. Primary structure and function of stromelysin/transin in cartilage matrix turnover. Wilhelm, S.M., Wunderlich, D., Maniglia, C.A., Eisen, A.Z., Goldberg, G.I. Matrix (Stuttgart, Germany). Supplement. (1992) [Pubmed]
  20. Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells. López-Barahona, M., Fialka, I., González-Sancho, J.M., Asunción, M., González, M., Iglesias, T., Bernal, J., Beug, H., Muñoz, A. EMBO J. (1995) [Pubmed]
  21. Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. Suzuki, Y., Nagai, N., Umemura, K., Collen, D., Lijnen, H.R. J. Thromb. Haemost. (2007) [Pubmed]
  22. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. Pei, D. J. Biol. Chem. (1999) [Pubmed]
  23. Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines. Zhou, J.N., Ljungdahl, S., Röhme, D., Levan, G., Shoshan, M.C., Linder, S. Genes Chromosomes Cancer (1997) [Pubmed]
  24. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. Suzuki, M., Raab, G., Moses, M.A., Fernandez, C.A., Klagsbrun, M. J. Biol. Chem. (1997) [Pubmed]
  25. Structural alterations at the neuromuscular junctions of matrix metalloproteinase 3 null mutant mice. VanSaun, M., Herrera, A.A., Werle, M.J. J. Neurocytol. (2003) [Pubmed]
  26. Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Crocker, S.J., Milner, R., Pham-Mitchell, N., Campbell, I.L. J. Neurochem. (2006) [Pubmed]
  27. Osteoactivin upregulates expression of MMP-3 and MMP-9 in fibroblasts infiltrated into denervated skeletal muscle in mice. Ogawa, T., Nikawa, T., Furochi, H., Kosyoji, M., Hirasaka, K., Suzue, N., Sairyo, K., Nakano, S., Yamaoka, T., Itakura, M., Kishi, K., Yasui, N. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  28. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. Zhou, J., Stohlman, S.A., Atkinson, R., Hinton, D.R., Marten, N.W. J. Virol. (2002) [Pubmed]
  29. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Kusano, K., Miyaura, C., Inada, M., Tamura, T., Ito, A., Nagase, H., Kamoi, K., Suda, T. Endocrinology (1998) [Pubmed]
  30. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. Das, S.K., Yano, S., Wang, J., Edwards, D.R., Nagase, H., Dey, S.K. Dev. Genet. (1997) [Pubmed]
  31. Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development. Witty, J.P., Wright, J.H., Matrisian, L.M. Mol. Biol. Cell (1995) [Pubmed]
  32. Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivation. Silence, J., Lupu, F., Collen, D., Lijnen, H.R. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
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