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Gene Review:

lin-5 - Protein LIN-5

Caenorhabditis elegans

Fisk Green, R. et al., Lorson, M.A. et al., Way, J.C. et al., Horvitz, H.R. et al.

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High impact information on lin-5

The Caenorhabditis elegans gene lin-5 is essential for multiple aspects of cell division [1].
Cells in lin-5 null mutants enter mitosis at the normal time and form bipolar spindles, but fail chromosome alignment at the metaphase plate, sister chromatid separation, and cytokinesis [1].
In a lin-5 mutant, in which postembryonic blast cells do not complete cell division and become polyploid, blast cells that would give rise to mec-3-expressing daughters instead express mec-3 themselves [2].
The Caenorhabditis elegans gene lin-5 encodes a novel coiled-coil component of the spindle required for spindle positioning and chromosome segregation [3].
To gain further insights into lin-5 function, we screened for dominant suppressors of the partial loss-of-function phenotype associated with the mutation lin-5(ev571ts ), and isolated 68 suppressing mutations [3].

Other interactions of lin-5

For some of these genes (lin-5, lin-6, unc-59, unc-85), this nonspecificity probably reflects a general utilization of their products in cellular replication [4].

References

LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans. Lorson, M.A., Horvitz, H.R., van den Heuvel, S. J. Cell Biol. (2000) [Pubmed]
Regulation of anterior cell-specific mec-3 expression during asymmetric cell division in C. elegans. Way, J.C., Run, J.Q., Wang, A.Y. Dev. Dyn. (1992) [Pubmed]
Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5. Fisk Green, R., Lorson, M., Walhout, A.J., Vidal, M., van den Heuvel, S. Mol. Genet. Genomics (2004) [Pubmed]
Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Horvitz, H.R., Sternberg, P.W., Greenwald, I.S., Fixsen, W., Ellis, H.M. Cold Spring Harb. Symp. Quant. Biol. (1983) [Pubmed]

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