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Gene Review:

unc-59 - Protein UNC-59

Caenorhabditis elegans

Nguyen, T.Q. et al., Horvitz, H.R. et al., Finger, F.P. et al.

Finger, Kopish, White,

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High impact information on unc-59

In this study, we show that both the unc-59 and unc-61 loci encode Caenorhabditis elegans septins [1].
For some of these genes (lin-5, lin-6, unc-59, unc-85), this nonspecificity probably reflects a general utilization of their products in cellular replication [2].

Biological context of unc-59

These defects can be at least partially attributed to failures in post-embryonic cytokineses although our data also suggest other possible roles for septins. unc-59 and unc-61 double mutants show similar defects to each of the single mutants [1].
Surprisingly, unc-59 and unc-61 mutants generally have normal embryonic development; however, defects were observed in post-embryonic development affecting the morphogenesis of the vulva, male tail, gonad, and sensory neurons [1].
Genomic database searches indicate that unc-59 and unc-61 are probably the only septin genes in the C. elegans genome [1].

Other interactions of unc-59

Caenorhabditis elegans has two genes, unc-59 and unc-61, encoding septin-family GTPases [3].

References

The C. elegans septin genes, unc-59 and unc-61, are required for normal postembryonic cytokineses and morphogenesis but have no essential function in embryogenesis. Nguyen, T.Q., Sawa, H., Okano, H., White, J.G. J. Cell. Sci. (2000) [Pubmed]
Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Horvitz, H.R., Sternberg, P.W., Greenwald, I.S., Fixsen, W., Ellis, H.M. Cold Spring Harb. Symp. Quant. Biol. (1983) [Pubmed]
A role for septins in cellular and axonal migration in C. elegans. Finger, F.P., Kopish, K.R., White, J.G. Dev. Biol. (2003) [Pubmed]

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