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Gene Review

klp-17  -  Protein KLP-17

Caenorhabditis elegans

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High impact information on klp-17

  • We additionally found that, although the failure of first polar body extrusion observed in alpha-Aurora A-microinjected oocytes is likely mediated by Eg5, the impairment of the metaphase plate rotation does not involve this kinesin-like protein [1].
  • One intriguing hypothesis is that AIR-2 acts to localize the mitotic kinesin-like protein ZEN-4 (also known as CeMKLP1), which later functions in cytokinesis [2].
  • Similarly, the klp-17 RNA interference assay results in embryonic death, arrested embryos, and polyploid cells [3].

Analytical, diagnostic and therapeutic context of klp-17


  1. Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes. Castro, A., Mandart, E., Lorca, T., Galas, S. J. Biol. Chem. (2003) [Pubmed]
  2. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Severson, A.F., Hamill, D.R., Carter, J.C., Schumacher, J., Bowerman, B. Curr. Biol. (2000) [Pubmed]
  3. cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans. Ali, M.Y., Siddiqui, S.S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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