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Gene Review

klp-16  -  Protein KLP-16

Caenorhabditis elegans

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High impact information on klp-16

  • We additionally found that, although the failure of first polar body extrusion observed in alpha-Aurora A-microinjected oocytes is likely mediated by Eg5, the impairment of the metaphase plate rotation does not involve this kinesin-like protein [1].
  • One intriguing hypothesis is that AIR-2 acts to localize the mitotic kinesin-like protein ZEN-4 (also known as CeMKLP1), which later functions in cytokinesis [2].
  • Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4 [3].
  • Conceptual translation of the klp-3 gene reveals a kinesin-like protein with its conserved motor domain containing the ATP binding and microtubule binding sites located in the C terminus [4].
  • Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16 [5].

Biological context of klp-16


Other interactions of klp-16


  1. Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes. Castro, A., Mandart, E., Lorca, T., Galas, S. J. Biol. Chem. (2003) [Pubmed]
  2. The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Severson, A.F., Hamill, D.R., Carter, J.C., Schumacher, J., Bowerman, B. Curr. Biol. (2000) [Pubmed]
  3. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Raich, W.B., Moran, A.N., Rothman, J.H., Hardin, J. Mol. Biol. Cell (1998) [Pubmed]
  4. Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd. Khan, M.L., Gogonea, C.B., Siddiqui, Z.K., Ali, M.Y., Kikuno, R., Nishikawa, K., Siddiqui, S.S. J. Mol. Biol. (1997) [Pubmed]
  5. A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans. Ali, M.Y., Siddiqui, Z.K., Malik, A.B., Siddiqui, S.S. FEBS Lett. (2000) [Pubmed]
  6. C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein. Shakir, M.A., Fukushige, T., Yasuda, H., Miwa, J., Siddiqui, S.S. Neuroreport (1993) [Pubmed]
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