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Gene Review

klp-15  -  Protein KLP-15

Caenorhabditis elegans

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High impact information on kinesins

  • We propose that kinesin II is a "canonical" IFT motor, whereas OSM-3 is an "accessory" IFT motor, and that subtle changes in the deployment or actions of these IFT kinesins can contribute to differences in cilia morphology, cilia function, and sensory perception [1].
  • Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd [2].
  • Common to all eukaryotes, kinesins are cytoskeletal motor proteins that mediate intracellular transport on microtubule tracks, using ATP hydrolysis [2].
  • Twenty kinesins have been found in the Caenorhabditis elegans genome, and four of these belong to the kinesin-14 subfamily, i.e., kinesins with C-terminal motor domains [3].
  • Kinesins form a superfamily of molecular motors involved in cell division and intracellular transport [3].

Biological context of kinesins


Other interactions of kinesins

  • Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16 [5].


  1. Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans. Evans, J.E., Snow, J.J., Gunnarson, A.L., Ou, G., Stahlberg, H., McDonald, K.L., Scholey, J.M. J. Cell Biol. (2006) [Pubmed]
  2. Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd. Khan, M.L., Gogonea, C.B., Siddiqui, Z.K., Ali, M.Y., Kikuno, R., Nishikawa, K., Siddiqui, S.S. J. Mol. Biol. (1997) [Pubmed]
  3. Essential kinesins: characterization of Caenorhabditis elegans KLP-15. Robin, G., DeBonis, S., Dornier, A., Cappello, G., Ebel, C., Wade, R.H., Thierry-Mieg, D., Kozielski, F. Biochemistry (2005) [Pubmed]
  4. Metazoan motor models: kinesin superfamily in C. elegans. Siddiqui, S.S. Traffic (2002) [Pubmed]
  5. A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans. Ali, M.Y., Siddiqui, Z.K., Malik, A.B., Siddiqui, S.S. FEBS Lett. (2000) [Pubmed]
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