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Gene Review

unc-103  -  Protein UNC-103

Caenorhabditis elegans

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Psychiatry related information on unc-103


High impact information on unc-103

  • Mutations in the unc-103 potassium channel gene suppress a gain-of-function phenotype of unc-43 in one tissue without affecting other tissues; thus, UNC-103 may be a tissue-specific target of CaMKII in vivo [2].
  • The unc-103 locus contains 6 promoter regions that express unc-103 in different combinations of body-wall and sex-specific muscles, motor-, inter- and sensory-neurons [1].
  • Also, reduction in acetylcholine suppresses unc-103-induced protraction, suggesting that UNC-103 keeps cholinergic neurons from stimulating the protractors before mating behavior [3].
  • Loss-of-function mutations in the unc-103 ERG-like K(+) channel gene cause the protractor muscles to contract in the absence of mating stimulation. unc-103-induced spicule protraction can be suppressed by killing the SPC motor neurons and the anal depressor muscle: cells that directly contact the protractors [3].


  1. Behavioral genetics of caenorhabditis elegans unc-103-encoded erg-like K(+) channel. Reiner, D.J., Weinshenker, D., Tian, H., Thomas, J.H., Nishiwaki, K., Miwa, J., Gruninger, T., Leboeuf, B., Garcia, L.R. J. Neurogenet. (2006) [Pubmed]
  2. Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II. Reiner, D.J., Newton, E.M., Tian, H., Thomas, J.H. Nature (1999) [Pubmed]
  3. Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating. Garcia, L.R., Sternberg, P.W. J. Neurosci. (2003) [Pubmed]
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