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Gene Review

Kcnh7  -  potassium voltage-gated channel, subfamily...

Mus musculus

Synonyms: 9330137I11Rik, ERG-3, Eag-related protein 3, Erg3, Ether-a-go-go-related gene potassium channel 3, ...
 
 
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Disease relevance of Kcnh7

  • To assess fluconazole efficacy in a murine model of disseminated candidiasis, inoculum sizes of the control and the erg3 homozygote were chosen which provided a similar organ burden [1].
 

High impact information on Kcnh7

  • For in vivo studies, a wild-type URA3 was placed back into its native locus in the erg3 homozygote to avoid positional effects on URA3 expression [1].
  • Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance [1].
  • A marked attenuation of virulence was shown by the longer survival and the lower kidney burdens of mice inoculated with the reconstituted Ura+ erg3 homozygote relative to the control [1].
  • In this study, we created a C. albicans erg3/erg3 mutant by the "Ura-blaster" method and confirmed the expected azole resistance using standard in vitro testing and the presence of ergosta-7,22-dien-3beta-ol instead of ergosterol [1].
  • ERG channels are encoded by different genes: the erg1 gene, which can generate two alternative transcripts (erg1a and erg1b), erg2 and erg3 [2].
 

Biological context of Kcnh7

  • Both in situ hybridisation and RNase Protection Assay experiments were used to study the expression pattern of mouse (m)erg1, m-erg2 and m-erg3 genes during mouse embryo development, to allow the pattern to be compared with their expression in the adult [3].
  • To test this hypothesis, the virulence of the erg3 mutants was assayed by using a mouse systemic infection model [4].
 

Other interactions of Kcnh7

  • Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3 [3].

References

  1. Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance. Miyazaki, T., Miyazaki, Y., Izumikawa, K., Kakeya, H., Miyakoshi, S., Bennett, J.E., Kohno, S. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. Guasti, L., Cilia, E., Crociani, O., Hofmann, G., Polvani, S., Becchetti, A., Wanke, E., Tempia, F., Arcangeli, A. J. Comp. Neurol. (2005) [Pubmed]
  3. Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Polvani, S., Masi, A., Pillozzi, S., Gragnani, L., Crociani, O., Olivotto, M., Becchetti, A., Wanke, E., Arcangeli, A. Gene Expr. Patterns (2003) [Pubmed]
  4. Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans. Chau, A.S., Gurnani, M., Hawkinson, R., Laverdiere, M., Cacciapuoti, A., McNicholas, P.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
 
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