Disease relevance of KCNH7

• Transcripts for HERG1 were present in all adenomas and although transcripts for HERG2 and HERG3 were also detected, their expression level was more variable [1].

High impact information on KCNH7

• ErgTx1 is unable to block hERG2, but blocks rERG2 and has the lowest KD for hERG3 [2].
• The erg genes known to date (erg1, erg2, and erg3) are highly expressed in various areas of the rat and mouse central nervous system (CNS), and ERG channel blockers alter firing accommodation [2].
• The influence of ERG on insulin secretion was monitored by perfusion of rat INS-1 beta-cells with the blockers E-4031 and rBeKm-1.We identified Erg1a, Erg1b, Erg2 and Erg3 transcripts in islets and INS-1 cells [3].
• KTC exposure induced transcription of genes involved in lipid, fatty acid, and sterol metabolism, including ERG11, ERG3, ERG25, ERG6, ERG26, ERG24, ERG4, CPO, INO1, DW700960, CPR, DW696584, DW406350, and ATG15 [4].
• Block of erg3 by sertindole also displayed a positive voltage-dependence [5].

Biological context of KCNH7

• Transient expression of erg3 in Chinese hamster ovary cells produced outwardly directed K(+) currents that activated at approximately -50 mV and produced a large transient component at positive membrane potentials [5].

Anatomical context of KCNH7

• Within the brain, erg3 was expressed in higher amounts in the frontal lobe and cerebellum relative to the temporal, parietal and occipital lobes [5].

Associations of KCNH7 with chemical compounds

• Pimozide blocked erg3 channel currents with an IC(50) of 103 nM and significant inhibition was noted at concentrations of 10 nM and higher [5].

Other interactions of KCNH7

• For comparison, corresponding values were obtained for heterologously expressed rat erg1, erg2 and erg3 channels [1].

Analytical, diagnostic and therapeutic context of KCNH7

• Immunohistochemistry was used to identify the pancreatic distribution patterns of ERG1a and ERG1b, as well as ERG2 and ERG3 [3].

References