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Gene Review

unc-43  -  Protein UNC-43

Caenorhabditis elegans

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High impact information on unc-43

  • Based on genetic epistasis analysis, nsy-1 appears to act downstream of the CaMKII unc-43, and NSY-1 associates with UNC-43, suggesting that UNC-43/CaMKII activates the NSY-1 MAP kinase cassette [1].
  • Mutations in the unc-103 potassium channel gene suppress a gain-of-function phenotype of unc-43 in one tissue without affecting other tissues; thus, UNC-103 may be a tissue-specific target of CaMKII in vivo [2].
  • Null unc-43 mutations cause phenotypes generally opposite to those of the gain-of-function mutation [2].
  • Interestingly, these characteristic defects resembled phenotypes observed in gain-of-function mutants of unc-43/Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) and goa-1/G(o)-protein alpha-subunit [3].
  • The slo-1 and egl-30 mutations conferred resistance to VAs, but unc-43 mutations did not [4].

Biological context of unc-43


Associations of unc-43 with chemical compounds

  • These were recovered from a lambda gt 10 library of DNA from a specially constructed genetic strain containing the unc-43 to unc-31 interval from the BO strain and the rest of the genome from N2 [5].


  1. The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Sagasti, A., Hisamoto, N., Hyodo, J., Tanaka-Hino, M., Matsumoto, K., Bargmann, C.I. Cell (2001) [Pubmed]
  2. Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II. Reiner, D.J., Newton, E.M., Tian, H., Thomas, J.H. Nature (1999) [Pubmed]
  3. Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans. Bandyopadhyay, J., Lee, J., Lee, J., Lee, J.I., Yu, J.R., Jee, C., Cho, J.H., Jung, S., Lee, M.H., Zannoni, S., Singson, A., Kim, d.o. .H., Koo, H.S., Ahnn, J. Mol. Biol. Cell (2002) [Pubmed]
  4. Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans. Hawasli, A.H., Saifee, O., Liu, C., Nonet, M.L., Crowder, C.M. Genetics (2004) [Pubmed]
  5. Cloning within the unc-43 to unc-31 interval (linkage group IV) of the Caenorhabditis elegans genome using Tc1 linkage selection. Baillie, D.L., Beckenbach, K.A., Rose, A.M. Can. J. Genet. Cytol. (1985) [Pubmed]
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