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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hmg-1.2  -  Protein HMG-1.2

Caenorhabditis elegans

 
 
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High impact information on hmg-1.2

  • P2 signaling downregulates an HMG domain protein, POP-1, in one EMS daughter [1].
  • pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos [2].
  • Finally, the HMG protein POP-1, a downstream component of the Wnt signalling pathway, has recently been shown to be important in many anterior/posterior fate decisions during C. elegans embryogenesis (Lin, R., Hill, R. J. and Priess, J. R. (1998) Cell 92, 229-239) [3].
  • In lymphocyte differentiation, several HMG box proteins play a decisive role [4].

References

  1. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Thorpe, C.J., Schlesinger, A., Carter, J.C., Bowerman, B. Cell (1997) [Pubmed]
  2. pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Lin, R., Thompson, S., Priess, J.R. Cell (1995) [Pubmed]
  3. Anterior-posterior patterning within the Caenorhabditis elegans endoderm. Schroeder, D.F., McGhee, J.D. Development (1998) [Pubmed]
  4. HMG box containing transcription factors in lymphocyte differentiation. Schilham, M.W., Clevers, H. Semin. Immunol. (1998) [Pubmed]
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