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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

hipr-1  -  Protein HIPR-1

Caenorhabditis elegans

 
 
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High impact information on Talin

  • Reduction of talin expression caused severe defects in gonad formation because of aberrant distal tip cell migration and also disrupted oocyte maturation and gonad sheath cell structure [1].
  • We have found that talin, a cytoskeletal-associated protein and focal adhesion component, is expressed in the distal tip cell and plays a central role in regulating its migration [1].
  • Either the dominant negative mutant pat-3 beta integrin or disruption of talin expression block ovulation [2].
 

Biological context of Talin

  • These in vivo analyses show that talin is required not only for strong adhesion and cytoskeletal organization by contractile cells, but also for dynamic regulation of integrin signals during cell migration [1].

References

  1. Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans. Cram, E.J., Clark, S.G., Schwarzbauer, J.E. J. Cell. Sci. (2003) [Pubmed]
  2. Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans. Xu, X., Lee, D., Shih, H.Y., Seo, S., Ahn, J., Lee, M. FEBS Lett. (2005) [Pubmed]
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