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Gene Review

pat-3  -  Protein PAT-3

Caenorhabditis elegans

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Disease relevance of pat-3

  • Sterility caused by RNAi of pat-3 and ECM molecules was suppressed by increased IP(3) signaling [1].

High impact information on pat-3

  • At least nine protein bands with relative molecular weights in the range observed for known integrin alpha subunits coprecipitate with beta pat-3, and at least three of these bands migrate in SDS-PAGE with increased mobility when reduced [2].
  • Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans [2].
  • Finally, immunocytochemical analysis revealed that beta pat-3 is expressed in the embryo and in many cell types postembryonically, including muscle, somatic gonad, and coelomocytes, suggesting multiple roles for integrin heterodimers containing this beta subunit in the developing animal [2].
  • Contractile muscle cells showed disorganization of the actin cytoskeleton leading to complete paralysis, a phenotype that was also observed with depletion of pat-2 and pat-3 integrins [3].
  • Either the dominant negative mutant pat-3 beta integrin or disruption of talin expression block ovulation [1].

Biological context of pat-3


Analytical, diagnostic and therapeutic context of pat-3

  • Immunoblot analysis using a polyclonal antiserum against the cytoplasmic domain showed that beta pat-3 migrates in SDS-PAGE with apparent M(r) of 109 k and 120 k under nonreducing and reducing conditions, respectively [2].
  • Immunoprecipitations of beta pat-3 from developmentally staged populations of C. elegans showed that the expression of several of these bands changes during development [2].


  1. Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans. Xu, X., Lee, D., Shih, H.Y., Seo, S., Ahn, J., Lee, M. FEBS Lett. (2005) [Pubmed]
  2. Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. Gettner, S.N., Kenyon, C., Reichardt, L.F. J. Cell Biol. (1995) [Pubmed]
  3. Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans. Cram, E.J., Clark, S.G., Schwarzbauer, J.E. J. Cell. Sci. (2003) [Pubmed]
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