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Gene Review

tax-4  -  Protein TAX-4

Caenorhabditis elegans

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Psychiatry related information on tax-4

  • The tax-4 and tax-2 genes of Caenorhabditis elegans are essential for normal olfaction, gustation, and thermosensation, suggesting that they have a role in sensory transduction [1].

High impact information on tax-4

  • We show that mutations in tax-2 or tax-4 disrupt social feeding, and that tax-4 is required in several neurons for social feeding, including one or more of AQR, PQR and URX [2].
  • Mutations in cmk-1 and tax-4 result in temperature-dependent defects in AFD-specific gene expression, and TAX-4 functions are required during larval stages to maintain gene expression in the adult [3].
  • Laser ablation and gene expression studies suggest that AFD neurons are not important, and tax-4 expression in neurons other than AFD is required, for warm avoidance [4].
  • We identified a gene in the C. elegans genome, which we designated cng-1, that is highly homologous to tax-4 [5].
  • Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35 [6].

Biological context of tax-4

  • Several classes of mutants (dyf, daf-3, tax-4, and tax-2) that are defective in dauer formation at lower temperatures reverse their phenotypes at 27 degrees and form dauers constitutively [7].

Associations of tax-4 with chemical compounds

  • NPR-1 activity in AQR, PQR and URX neurons seems to suppress social feeding by antagonizing signalling through a cyclic GMP-gated ion channel encoded by tax-2 and tax-4 [2].

Other interactions of tax-4

  • Here we show that, in tax-2 and tax-4 mutants, young larvae have superficially normal axons, but axon outgrowth resumes in inappropriate regions in late larval stages [8].


  1. Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Komatsu, H., Jin, Y.H., L'Etoile, N., Mori, I., Bargmann, C.I., Akaike, N., Ohshima, Y. Brain Res. (1999) [Pubmed]
  2. Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans. Coates, J.C., de Bono, M. Nature (2002) [Pubmed]
  3. The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Satterlee, J.S., Ryu, W.S., Sengupta, P. Curr. Biol. (2004) [Pubmed]
  4. Distribution and movement of Caenorhabditis elegans on a thermal gradient. Yamada, Y., Ohshima, Y. J. Exp. Biol. (2003) [Pubmed]
  5. Identification and characterization of a putative cyclic nucleotide-gated channel, CNG-1, in C. elegans. Cho, S.W., Cho, J.H., Song, H.O., Park, C.S. Mol. Cells (2005) [Pubmed]
  6. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Gray, J.M., Karow, D.S., Lu, H., Chang, A.J., Chang, J.S., Ellis, R.E., Marletta, M.A., Bargmann, C.I. Nature (2004) [Pubmed]
  7. Dauer formation induced by high temperatures in Caenorhabditis elegans. Ailion, M., Thomas, J.H. Genetics (2000) [Pubmed]
  8. A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Coburn, C.M., Mori, I., Ohshima, Y., Bargmann, C.I. Development (1998) [Pubmed]
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