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Gene Review:

cmk-1 - Protein CMK-1

Caenorhabditis elegans

Min, D.S. et al., Satterlee, J.S. et al., Trailovic, S.M. et al., Troemel, E.R. et al.

Min, Cho, Yoon, Lee, Hahn, Lee, Kim, Jo,

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High impact information on cmk-1

This interaction induces str-2 expression by reducing calcium signaling through a voltage-dependent Ca2+ channel and the CaM kinase II UNC-43 [1].
Mutations in cmk-1 and tax-4 result in temperature-dependent defects in AFD-specific gene expression, and TAX-4 functions are required during larval stages to maintain gene expression in the adult [2].
Moreover, the Ca(2+)-calmodulin-dependent protein kinase II (CaM kinase II) inhibitor KN62, in addition to chelation of extracellular or intracellular Ca(2+) by EGTA and BAPTA/AM, abolished CCh-induced PLD activation and protein tyrosine phosphorylation [3].
A model involving calcium release from the sarcoplasmic reticulum, CaM Kinase, calcineurin, muscarinic receptors and AF2 receptors is proposed to explain our observations [4].

References

Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Troemel, E.R., Sagasti, A., Bargmann, C.I. Cell (1999) [Pubmed]
The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Satterlee, J.S., Ryu, W.S., Sengupta, P. Curr. Biol. (2004) [Pubmed]
Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans. Min, D.S., Cho, N.J., Yoon, S.H., Lee, Y.H., Hahn, S.J., Lee, K.H., Kim, M.S., Jo, Y.H. J. Neurochem. (2000) [Pubmed]
Brief application of AF2 produces long lasting potentiation of nAChR responses in Ascaris suum. Trailovic, S.M., Clark, C.L., Robertson, A.P., Martin, R.J. Mol. Biochem. Parasitol. (2005) [Pubmed]

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AgaP_AGAP005306	Anopheles gambiae str. PEST
CDPK9	Arabidopsis thaliana
camk1a	Danio rerio
CaMKI	Drosophila melanogaster

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